N-{7-[1-(4-tert-butylphenoxy)-1-methyl-ethyl]-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}-N'-methoxy-formamidine | 1246303-37-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-{7-[1-(4-tert-butylphenoxy)-1-methyl-ethyl]-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}-N'-methoxy-formamidine
• 英文别名: N'-[7-[2-(4-tert-butylphenoxy)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]-N-methoxymethanimidamide
• CAS: 1246303-37-6
• 化学式: C₂₀H₂₆N₆O₂
• 分子量: 382.465
• InChiKey: IYJQZYCFPMIREK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  85.9
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS
  申请人：Sørensen Ulrik Svane

  公开号：US20120095025A1

  公开（公告）日：2012-04-19

  This invention relates to novel substituted [1,2,4]triazolo[1,5-a]pyrimidines useful as modulators of potassium channels. In other aspects the invention relates to the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention. Formula (I).