6-(2-(pyridin-4-yl)ethyl)-1,3,8-trimethoxyanthraquinone | 1206898-27-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 6-(2-(pyridin-4-yl)ethyl)-1,3,8-trimethoxyanthraquinone
• CAS: 1206898-27-2
• 化学式: C₂₄H₂₁NO₅
• 分子量: 403.434
• InChiKey: KQSBUKWXBKDWPD-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  6-(2-(pyridin-4-yl)ethyl)-1,3,8-trimethoxyanthraquinone 在 tin(II) chloride dihdyrate 、 氢溴酸 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 1.0h， 以85%的产率得到1,3,8-trihydroxy-6-(2-(pyridin-4-yl)ethyl)-10H-anthracen-9-one
  参考文献：
  名称：

  Cationic Hypericin Derivatives as Novel Agents with Photobactericidal Activity: Synthesis and Photodynamic Inactivation ofPropionibacterium acnes

  摘要：

  AbstractThe present communication describes for the first time the synthesis and preliminary testing of two cationic hypericin derivatives. Uncharged hypericin derivatives with ω,ω’‐attached C2‐linkers leading to a pyridyl or a 4‐dimethylaminophenyl residue were prepared and subsequently quaternized by means of iodomethane. Photobactericidal activity was assessed using Propionibacterium acnes. The quaternary N,N,N‐trimethyl‐anilinium derivative displayed a pronounced photodynamic inactivation of the bacteria at low incubation concentrations (<100 nm) and a short incubation time (1 h) after illumination with yellow light (590 nm, 20 J cm−2), whereas the photobactericidal efficacy of the N‐methyl‐pyridinium derivative was negligible under identical experimental conditions.

  DOI：

  10.1111/j.1751-1097.2009.00587.x
• 作为产物：
  描述：

  6-(2-(pyridin-4-yl)vinyl)-1,3,8-trimethoxyanthraquinone 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 20.0h， 以96%的产率得到6-(2-(pyridin-4-yl)ethyl)-1,3,8-trimethoxyanthraquinone
  参考文献：
  名称：

  Cationic Hypericin Derivatives as Novel Agents with Photobactericidal Activity: Synthesis and Photodynamic Inactivation ofPropionibacterium acnes

  摘要：

  AbstractThe present communication describes for the first time the synthesis and preliminary testing of two cationic hypericin derivatives. Uncharged hypericin derivatives with ω,ω’‐attached C2‐linkers leading to a pyridyl or a 4‐dimethylaminophenyl residue were prepared and subsequently quaternized by means of iodomethane. Photobactericidal activity was assessed using Propionibacterium acnes. The quaternary N,N,N‐trimethyl‐anilinium derivative displayed a pronounced photodynamic inactivation of the bacteria at low incubation concentrations (<100 nm) and a short incubation time (1 h) after illumination with yellow light (590 nm, 20 J cm−2), whereas the photobactericidal efficacy of the N‐methyl‐pyridinium derivative was negligible under identical experimental conditions.

  DOI：

  10.1111/j.1751-1097.2009.00587.x