3-[3-[(4-aminosulfonyl)phenyl]-4-(4-chlorophenyl)-1H-pyrazol-1-yl]-N-hydroxy-N-methyl-2-propynamide | 425418-37-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[3-[(4-aminosulfonyl)phenyl]-4-(4-chlorophenyl)-1H-pyrazol-1-yl]-N-hydroxy-N-methyl-2-propynamide
• 英文别名: 3-[4-(4-chlorophenyl)-3-(4-sulfamoylphenyl)pyrazol-1-yl]-N-hydroxy-N-methylprop-2-ynamide
• CAS: 425418-37-7
• 化学式: C₁₉H₁₅ClN₄O₄S
• 分子量: 430.871
• InChiKey: RWIWIPSLNIDINV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
  申请人：Pharmacia Corporation

  公开号：US20020058810A1

  公开（公告）日：2002-05-16

  This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.

  这项发明属于抗炎药物代理领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶介导的疾病的化合物、组合物和方法，如炎症。
• HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS
  申请人：G.D. SEARLE & CO.

  公开号：EP0828718A1

  公开（公告）日：1998-03-18
• [EN] HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS<br/>[FR] DERIVES HETEROCYCLO-SUBSTITUES D'ACIDE HYDROXAMIQUE UTILISES COMME INHIBITEURS DE LA CYCLO-OXYGENASE-2 ET DE LA 5-LIPOXYGENASE
  申请人：G.D. SEARLE & CO.

  公开号：WO1996038418A1

  公开（公告）日：1996-12-05

  (EN) This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds of formula (I), compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase such as inflammation.(FR) La présente invention a trait au domaine des agents pharmaceutiques anti-inflammatoires et concerne de manière spécifique des composés de formule (I), des compositions et des méthodes permettant de traiter des troubles induits par la cyclo-oxygénase-2 ou par la 5-lipoxygénase, tels que l'inflammation.