N'-{(1S)-2-amino-1-(3,5-difluorobenzyl)-3-[(6-ethylpyridin-2-yl)methoxy]propyl}-5-(1,3-oxazol-2-yl)-N,N-dipropylisophthalamide | 674809-88-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N'-{(1S)-2-amino-1-(3,5-difluorobenzyl)-3-[(6-ethylpyridin-2-yl)methoxy]propyl}-5-(1,3-oxazol-2-yl)-N,N-dipropylisophthalamide
• 英文别名: 1-N-[(2S)-3-amino-1-(3,5-difluorophenyl)-4-[(6-ethylpyridin-2-yl)methoxy]butan-2-yl]-5-(1,3-oxazol-2-yl)-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
• CAS: 674809-88-2
• 化学式: C₃₅H₄₁F₂N₅O₄
• 分子量: 633.738
• InChiKey: NQDLOKONVMOVQO-JYUUXGOASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  46
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Substituted aminoethers for the treatment of alzheimer's disease
  申请人：Beck P. James

  公开号：US20060194966A1

  公开（公告）日：2006-08-31

  The invention provides compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

  本发明提供了式（I）化合物：用于治疗阿尔茨海默病和其他类似疾病。这些化合物包括β-分泌酶的抑制剂，可用于治疗阿尔茨海默病和其他以哺乳动物体内Aβ肽沉积为特征的疾病。本发明的化合物可用于药物组合物和治疗方法，以减少 A beta 肽的形成。
• Substituted Aminoethers for the Treatment of Alzheimer's Disease
  申请人：Beck James P.

  公开号：US20090291970A1

  公开（公告）日：2009-11-26

  The invention provides compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
• US7566730B2
  申请人：——

  公开号：US7566730B2

  公开（公告）日：2009-07-28