8-tert-Butoxycarbonylamino-2-tert-butoxycarbonylmethyl-3-oxo-octahydro-indolizine-2-carboxylic acid methyl ester | 177158-10-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 8-tert-Butoxycarbonylamino-2-tert-butoxycarbonylmethyl-3-oxo-octahydro-indolizine-2-carboxylic acid methyl ester
• CAS: 177158-10-0
• 化学式: C₂₁H₃₄N₂O₇
• 分子量: 426.51
• InChiKey: JZJIOKWBAALGOL-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  8-tert-Butoxycarbonylamino-2-tert-butoxycarbonylmethyl-3-oxo-octahydro-indolizine-2-carboxylic acid methyl ester 在 sodium hydroxide 作用下， 生成 8-tert-Butoxycarbonylamino-2-tert-butoxycarbonylmethyl-3-oxo-octahydro-indolizine-2-carboxylic acid
  参考文献：
  名称：

  CCK-4 restricted analogues containing a 3-oxoindolizidine skeleton

  摘要：

  A series of CCK-4 restricted analogues, incorporating a 3-oxoindolizidine bicyclic lactam as conformational constraint, is described. The 8-(Boc-tryptophyl)amino-2-benzyl derivatives behave as weak CCK-A or CCK-B receptor antagonists. The main factors for selectivity are the configuration at C-2 position of the 3-oxoindolizidine ring and at the Trp residue. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00160-6
• 作为产物：
  描述：

  溴乙酸叔丁酯 、 8-tert-Butoxycarbonylamino-3-oxo-octahydro-indolizine-2-carboxylic acid methyl ester 在 sodium methylate 作用下， 生成 8-tert-Butoxycarbonylamino-2-tert-butoxycarbonylmethyl-3-oxo-octahydro-indolizine-2-carboxylic acid methyl ester
  参考文献：
  名称：

  CCK-4 restricted analogues containing a 3-oxoindolizidine skeleton

  摘要：

  A series of CCK-4 restricted analogues, incorporating a 3-oxoindolizidine bicyclic lactam as conformational constraint, is described. The 8-(Boc-tryptophyl)amino-2-benzyl derivatives behave as weak CCK-A or CCK-B receptor antagonists. The main factors for selectivity are the configuration at C-2 position of the 3-oxoindolizidine ring and at the Trp residue. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00160-6