(S)-tert-Butoxycarbonylamino-[4-((S)-tert-butoxycarbonylamino-carboxy-methyl)-phenyl]-acetic acid | 178869-24-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-tert-Butoxycarbonylamino-[4-((S)-tert-butoxycarbonylamino-carboxy-methyl)-phenyl]-acetic acid
• CAS: 178869-24-4
• 化学式: C₂₀H₂₈N₂O₈
• 分子量: 424.451
• InChiKey: ZEXQQKPPVZNTLM-KBPBESRZSA-N

反应信息

• 作为反应物：
  描述：

  (S)-tert-Butoxycarbonylamino-[4-((S)-tert-butoxycarbonylamino-carboxy-methyl)-phenyl]-acetic acid 在 三甲基氯硅烷 、 六甲基二硅氮烷 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 (S)-{4-[(S)-Carboxy-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phenyl}-[(9H-fluoren-9-ylmethoxycarbonylamino)]-acetic acid
  参考文献：
  名称：

  Asymmetric synthesis of phenylbis(glycines)

  摘要：

  (S,S)-alpha,alpha'-Diamino-1,4- and 1,3-benzenediacetic acids and N-Boc- and N-Fmoc-derivatives have been prepared by stereoselective syntheses. The chiral auxiliary (S)-4-benzyl-2-oxazolidinone formed bisimides with benzenediacetyl dichlorides The imides were lithiated at both a-sites to the carbonyl groups and azidated stereoselectively alpha to both carbonyl groups by trisyl azide to provide (S,S)-alpha,alpha'-diazidobenzenediacetic acid derivatives which were reduced to amines by Sn(II) chloride or by hydrogenolysis over Pd. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0040-4020(96)00344-4
• 作为产物：
  描述：

  二碳酸二叔丁酯 在 lithium hydroxide 、 碳酸氢钠 、 tin(ll) chloride 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 1.5h， 生成 (S)-tert-Butoxycarbonylamino-[4-((S)-tert-butoxycarbonylamino-carboxy-methyl)-phenyl]-acetic acid
  参考文献：
  名称：

  Asymmetric synthesis of phenylbis(glycines)

  摘要：

  (S,S)-alpha,alpha'-Diamino-1,4- and 1,3-benzenediacetic acids and N-Boc- and N-Fmoc-derivatives have been prepared by stereoselective syntheses. The chiral auxiliary (S)-4-benzyl-2-oxazolidinone formed bisimides with benzenediacetyl dichlorides The imides were lithiated at both a-sites to the carbonyl groups and azidated stereoselectively alpha to both carbonyl groups by trisyl azide to provide (S,S)-alpha,alpha'-diazidobenzenediacetic acid derivatives which were reduced to amines by Sn(II) chloride or by hydrogenolysis over Pd. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0040-4020(96)00344-4