7-[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]-3,4-dihydro-2H-chromen-4-ol | 1407167-76-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 7-[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]-3,4-dihydro-2H-chromen-4-ol
• 英文别名: 7-[1-(cyclopropylmethyl)-4-(trifluoromethyl)benzotriazol-5-yl]-3,4-dihydro-2H-chromen-4-ol
• CAS: 1407167-76-3
• 化学式: C₂₀H₁₈F₃N₃O₂
• 分子量: 389.377
• InChiKey: LSTAJOUKPYQYAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  60.2
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• ALHYDROXYMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES
  申请人：Beshore Douglas C.

  公开号：US20140088151A1

  公开（公告）日：2014-03-27

  The present invention is directed to hydroxymethyl biaryl benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及羟甲基双芳基苯并三唑衍生物，这些衍生物是代谢型谷氨酸受体的增强剂，特别是mGluR2受体，并且在治疗或预防与谷氨酸功能障碍有关的神经和精神障碍以及代谢型谷氨酸受体参与的疾病方面具有用处。本发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在预防或治疗代谢型谷氨酸受体参与的疾病方面的使用。