4-(1,1,2,2-四氟乙氧基)硝基苯 | 28202-32-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(1,1,2,2-四氟乙氧基)硝基苯
• 中文别名: 4-四氟乙氧基硝基苯
• 英文名称: 1-nitro-4-(1,1,2,2-tetrafluoroethoxy)-benzene
• 英文别名: 4-nitrotetrafluoroethoxybenzene；α,α,β,β-tetrafluoro-p-nitrophenetole；1-nitro-4-(1,1,2,2-tetrafluoroethoxy)benzene
• CAS: 28202-32-6
• 化学式: C₈H₅F₄NO₃
• mdl: MFCD00042450
• 分子量: 239.126
• InChiKey: VNSOCOWFQDIYTN-UHFFFAOYSA-N

物化性质

• 熔点：
  43-45°C
• 沸点：
  66-68/1mm
• 密度：
  1.48
• 闪点：
  >100
• 稳定性/保质期：
  如果按照规格使用和储存，则不会分解，也未有已知危险反应。

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  7

安全信息

• 危险等级：
  TOXIC
• 危险品标志：
  T
• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R23/24/25
• 海关编码：
  2909309090
• 危险品运输编号：
  UN 2810
• 储存条件：
  请将贮藏器密封，并将其存放在阴凉、干燥处。确保工作环境有良好的通风或排气设施。

SDS

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SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name : 1-NITRO-4-(1,1,2,2-
TETRAFLUOROETHOXY)BENZENE
REACH No. : A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
CAS-No. : 28202-32-6
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

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SECTION 2: Hazards identification
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 4), H302
Eye irritation (Category 2), H319
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Xn Harmful R22, R36
For the full text of the R-phrases mentioned in this Section, see Section 16.
Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal word Warning
Hazard statement(s)
H302 Harmful if swallowed.
H319 Causes serious eye irritation.
Precautionary statement(s)
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazard none
Statements
Other hazards - none

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SECTION 3: Composition/information on ingredients
Substances
Formula : C8H5F4NO3
Molecular Weight : 239,13 g/mol
CAS-No. : 28202-32-6
Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
1-NITRO-4-(1,1,2,2-TETRAFLUOROETHOXY)BENZENE
Acute Tox. 4; Eye Irrit. 2; -
H302, H319
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

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SECTION 4: First aid measures
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
no data available

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SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx), Hydrogen fluoride
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
adequate ventilation. Avoid breathing dust.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

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SECTION 7: Handling and storage
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end use(s)
A part from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.

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SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and no data available
boiling range
g) Flash point no data available
h) Evapouration rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- log Pow: 2,472
octanol/water
p) Auto-ignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5

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SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitisation
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: Not available
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.

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SECTION 12: Ecological information
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
no data available

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SECTION 13: Disposal considerations
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material. Dissolve or mix the material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

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SECTION 14: Transport information
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

---

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SECTION 15 - REGULATORY INFORMATION
N/A

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-(1,1,2,2-四氟乙氧基)硝基苯 在 乙酸酐 作用下， 以 乙醇 、 水 、 溶剂黄146 为溶剂， 生成 N-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-acetamide
  参考文献：
  名称：

  Fluoroalkoxy substituted benzimidazoles useful as gastric acid secretion

  摘要：

  式I的二烷氧基吡啶##STR1##其中R1是完全或主要由氟或氯二氟甲基取代的1-3C-烷基，R1'是氢、卤素、三氟甲基、1-3C-烷基或1-3C-烷氧基，后者可以选择性地完全或主要由氟取代，或R1和R1'连同与R1连接的氧原子一起，是1-2C-烷二氧基，后者可以选择性地完全或部分由氟取代，或氯三氟乙烯二氧基，R3是1-3C-烷氧基，R2和R4中的一个是1-3C-烷氧基，另一个是氢原子或1-3C-烷基，n为0或1，以及它们的盐是一种对胃具有显著保护作用的新化合物。揭示了制备这些化合物的方法，含有它们的药物及其用途，以及中间体化合物及其用途用于制备所述二烷氧基吡啶。

  公开号：

  US04758579A1
• 作为产物：
  描述：

  对硝基(苯)酚钾 、 1,1,2,2-四氟-1,2-二溴乙烷 以62%的产率得到
  参考文献：
  名称：

  RICO, I.;WAKSELMAN, C., J. FLUOR. CHEM., 1982, 20, N 6, 759-764

  摘要：

  DOI：

文献信息

• Picoline derivative useful as gastric acid secretion inhibitors
  申请人：Byk Gulden Lomberg Chemische Fabrik GmbH

  公开号：US04686230A1

  公开（公告）日：1987-08-11

  Picoline derivatives of the formula I ##STR1## wherein the substituents have the meanings given in the description, and their salts are new compounds having a pronounced protective action on the stomach.

  式I的吡啶醛衍生物##STR1##，其中取代基具有描述中给出的含义，它们的盐是一种对胃具有显著保护作用的新化合物。
• Facile and efficient synthesis of fluoroalkyl aryl ethers
  作者：Ahmed Kamal、T.B Pratap、K.Venkata Ramana、A.V Ramana、A.Hari Babu

  DOI：10.1016/s0040-4039(02)01719-7

  日期：2002.10

  A convenient and practical method for the preparation of fluoroalkyl aryl ethers via substitution of iodoalkyl fluorides is described. This method involves KF complexation of the phenol, which increases the nucleophilicity of oxygen for the formation of the ether linkage.

  描述了一种通过取代碘代烷基氟来制备氟代烷基芳基醚的方便实用的方法。该方法涉及苯酚的KF络合，这会增加氧的亲核性以形成醚键。
• Haloalkoxy-substituted diphenyl ethers; their use as herbicides and in herbicidal compositions and processes of making them
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0063873A1

  公开（公告）日：1982-11-03

  Compounds of the formula (I) wherein R' is C1-C2 haloalkyl containing F or Cl, X and Y are H, halogen, alkyl, CN, NO, or CF3; A is H, CH3, NO2, halogen, CN or CF3; and R2 is (a) -OH (b) -OM wherein M is a cation; (c) -OR3 wherein R3 is optionally substituted phenyl, alkyl, alkenyl or alkynyl (d) -NR4R5 wherein each group R4 and R5 is hydrogen or optionally substituted alkyl, alkenyl or phenyl or (e) -NHSO2R3 or -NMSO2R3. The compounds are useful as herbicides.

  式 (I) 的化合物 其中 R' 是含 F 或 Cl 的 C1-C2 卤代烷基，X 和 Y 是 H、卤素、烷基、CN、NO 或 CF3；A 是 H、CH3、NO2、卤素、CN 或 CF3；R2 是 (a) -OH (b) -OM 其中 M 是阳离子；(c) -OR3 其中 R3 是任选取代的苯基、烷基、烯基或炔基 (d) -NR4R5 其中每个基团 R4 和 R5 是氢或任选取代的烷基、烯基或苯基或 (e) -NHSO2R3 或 -NMSO2R3。 这些化合物可用作除草剂。
• Anti-sekretorische, Fluoralkoxy-substituierte Pyridylmethylthio-(oder sulfinyl-)benzimidazole
  申请人：Byk Gulden Lomberg Chemische Fabrik GmbH

  公开号：EP0134400A2

  公开（公告）日：1985-03-20

  Fluoralkoxyverbindungen der allgemeinen Formel 1 worin R1 einen ganz oder überwiegend durch Fluor substituierten 1-3C-Alkylrest oder einen Chlordifluormethylrest, R1' Wasserstoff, Halogen, Trifluormethyl, einen 1-3C-Alkylrest oder einen gegebenenfalls ganz oder überwiegend durch Fluor substituierten 1-3C-Alkoxyrest, R2 Wasserstoff oder einen 1-3C-Alkylrest, R3 Wasserstoff, einen 1-3C-Alkyl-oder einen 1-3C-Alkoxyrest, R4 Wasserstoff oder einen 1-3C-Alylrest und n die Zahlen 0 oder 1 darstellt, und ihre Salze sind neue Verbindungen mit ausgeprägter Magenschutzwirkung.

  式 1 的氟烷氧基化合物 其中 R1 是完全或主要由氟取代的 1-3C-烷基或氯二氟甲基，R1'是氢、卤素、三氟甲基、1-3C-烷基或可选的完全或主要由氟取代的 1-3C-烷氧基，R2 是氢或 1-3C-烷基，R3 是氢、1-3C-烷基或 1-3C-烷氧基，R4 是氢或 1-3C-烷基，n 是 0 或 1，它们的盐是具有明显胃保护活性的新化合物。
• Verfahren zur Herstellung von N-Alkyl-fluoranilinen
  申请人：BAYER AG

  公开号：EP0491968A1

  公开（公告）日：1992-07-01

  N-Alkyl-arylamine der Formel (I), in welcher Arfür einen Arylrest steht, welcher gegebenenfalls einfach oder mehrfach durch Halogen und/oder durch jeweils gegebenenfalls substituiertes Alkyl, Alkoxy und/oder Alkoxycarbonyl substituiert ist, R¹für Wasserstoff oder Alkyl steht und R²für jeweils gegebenenfalls substituiertes Alkyl oder Aryl steht oder zusammen mit R¹ für Alkandiyl steht, (welche als Zwischenprodukte zur Herstellung von landwirtschaftlich nutzbaren Stoffen, insbesondere von Herbiziden, verwendet werden können), erhält man in guten Ausbeuten und hoher Reinheit, indem man in einem "Ein-Topf-Verfahren" Nitroarene der Formel         Ar-NO₂   (II) mit Carbonylverbindungen der Formel         R¹-CO-R²   (III) in Gegenwart von Wasserstoff und in Gegenwart eines Katalysators bei Temperaturen zwischen 0° und 200°C, gegebenenfalls bei erhöhtem Druck, umsetzt.

  式 (I) 的 N-烷基芳基胺、 其中 Ar 代表芳基，该芳基可任选被卤素和/或任选被取代的烷基、烷氧基和/或烷氧羰基单取代或多取代、 R¹ 代表氢或烷基 R² 在每种情况下代表任选取代的烷基或芳基，或与 R¹ 一起代表烷二基、 (通过使用 "一锅法 "生产式如下的硝基烯烃，可获得高产率和高纯度的硝基烯烃（可用作生产对农业有用的物质，特别是除草剂的中间体）： 1. Ar-NO₂ (II) 与式 R¹-CO-R² (III) 在有氢气和催化剂存在的情况下，温度介于 0° 至 200°C，必要时在高压下进行。