[(1-benzyl-2-imidazolyl)diphenylphosphinegold(I)chloride] | 162020-48-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [(1-benzyl-2-imidazolyl)diphenylphosphinegold(I)chloride]
• 英文别名: chloro[(1-benzylimidazol-2-yl)diphenyl]phosphinegold(I)；[AuCl(1-benzyl-2-imidazolyl diphenylphosphine)]；(1-benzylimidazole-2-yl)Ph2PAuCl；(1-benzylimidazol-2-yl)-diphenylphosphane;chlorogold
• CAS: 162020-48-6
• 化学式: C₂₂H₁₉AuClN₂P
• 分子量: 574.8
• InChiKey: PUVWGEKBYGNWJK-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [(1-benzyl-2-imidazolyl)diphenylphosphinegold(I)chloride] 以 二氯甲烷 为溶剂， 生成 [((1-benzylimidazole-2-yl)Ph2PAuCl)2AuCl2]BF4
  参考文献：
  名称：

  三（1-苄基咪唑-2-基）膦的单核和四核金（I）配合物

  摘要：

  三（1-苄基咪唑-2-基）膦（Bzim）3 P，1与Ph 3 AsAuCl以化学计量比1：1的反应生成（Bzim）3 PAuCl，2。（Bzim）3 PAuCl与NaAuCl 4在二氯甲烷中以1：1的化学计量反应生成橙黄色结晶四核金（I）簇[{μ- N，N '-（Bzim）3 PAuCl} 2 Au 2 ] [ AuCl 2 ] [AuCl 4 ]，3。络合物4，[{μ- N，N '-（Bzim）3PAuCl} 2的Au 2 ] [AUCL 2 ] 2时（Bzim）的反应的化学计量形成3 PAuCl和AUCL 4 -为2：1。3的晶体结构表明形成了一个12元大环，Au···Au距离约为3.0Å。（Bzim）3 PAuCl和3的结构显示Au··· HC相互作用范围为2.57至2.95Å 。络合物2在单斜空间群P 2 1 / n（Z = 4）中结晶，a = 9.1927（5），b = 13.528（2），c=

  DOI：

  10.1021/ic901562d
• 作为产物：
  描述：

  氯(二甲基硫化)金(I) 、 (三苯基胂)金(I)氯化物 以 not given 为溶剂， 生成 [(1-benzyl-2-imidazolyl)diphenylphosphinegold(I)chloride]
  参考文献：
  名称：

  Dinuclear gold(I) and silver(I) derivatives with bridging phosphines containing an imidazole ring; X-ray crystal structure of (1-benzyl-2-imidazolyl)diphenylphosphinegold(I)chloride

  摘要：

  (1-苄基-2-咪唑基)二苯基膦 [(BzIm)Ph(2)P] 可以作为单齿或多齿配体，生成单核 (BzIm)Ph(2)PAuCl (I) 或双核 [μ-(BzIm)Ph(2)PAu](2+)(2)2X(-) (X = PF6-, BF4- 或 NO3-) (IIa,b,c) 的金(I)配合物。类似的双核银(I)配合物通过将配体 [(BzIm)Ph(2)P] 与 AgX 盐 (X=NO3-, BF4-) 反应获得 (IIIa,b)。在溶液中，银配合物表现出流动行为，通过 P-31 NMR 光谱观察到了两种构象。化合物 I 的结构通过 X 射线衍射确定（单斜系，空间群 C2/c，a = 18.068(2), b = 16.576(2), c = 15.391(2) 埃，β = 117.2(2) 度，Z = 8）。分子间较短的 Au-Au 距离为 3.03(2) 埃，表明存在金属-金属相互作用。化合物 I 和 IIa 的 Au-197 穆斯堡尔参数与红外光谱、NMR 和晶体学数据一致。

  DOI：

  10.1016/0020-1693(94)04258-w

文献信息

• Neutral mononuclear and dinuclear complexes of gold(I) featuring azole ligands: Synthesis, structure and cytotoxicity
  作者：William F. Gabrielli、Stefan D. Nogai、Margo Nell、Stephanie Cronje、Helgard G. Raubenheimer

  DOI：10.1016/j.poly.2011.12.026

  日期：2012.2

  The aim of this work was to extend the small library of existing compounds of gold(I) that contain pentafluorophenyl and thiazole ligands and to determine the biological activity of such compounds against a well-known cancer cell line. Seven mono and dinuclear new compounds that contain imidazole, thiazole and tetrazole rings were isolated and characterised. Three of the crystal structures determined indicated Au center dot center dot center dot Au interactions between constituent complex molecules. A simple adduct, [Au(C6F5)(N-methylimidazole)], exhibits a relatively high anti-tumour specificity indicating the viability of selected phosphine-free gold complexes as cytotoxic agents. (C) 2012 Elsevier Ltd. All rights reserved.
• Rhodium, iridium and gold complexes of the short-bite ligand 1-benzyl-2-imidazolyldiphenylphosphine
  作者：Cristina Tejel、Miguel A. Ciriano、Rita Bravi、Luis A. Oro、Claudia Graiff、Rossana Galassi、Alfredo Burini

  DOI：10.1016/s0020-1693(02)01447-0

  日期：2003.4

  Reactions of [M(mu-Cl)(cod)}(2)] (M = Rh, Ir) with 1-benzyl-2-imidazolyldiphenylphosphine gave the mononuclear P-bonded compounds [MCl(cod)(Ph(2)PBzIm)]. They react with [M(cod)(acetone)(x)]BF4 to give the cationic [M(cod)}(2)(mu-Cl)(mu-Ph(2)PBzIm)](+) complexes, while they react with silver salts to give the homometallic dinuclear complexes HT-[M(mu-Ph(2)PBzIm)(cod)}(2)](BF4)(2) (M = Rh, Ir) containing two mutually cis bridging ligands in a HT disposition. Addition of [AuCl(tht)] to [MCl(cod)(Ph(2)PBzIm)] gave the heterometallic complexes [MCl(cod)(mu-Ph(2)PBzIm)AuCl] with the gold atom coordinated to the P-end. While the Ir-Au compound remained as such in solution. the Rh-Au complex was found to be in equilibrium with [AuCl(Ph(2)PBzIm)] and [Rh(mu-Cl)(cod)}(2)]. Reaction of trans-[RhCl(CO)(Ph(2)PBzIm)(2)] with [Rh(mu-Cl)(CO)(2)}(2)] gave the 'A-frame' complex [RhCl}(2)(mu-CO)(mu-Ph(2)PBzIm)(2)] while the reaction with [PdCl2(NCMe)(2)] resulted in the formation of three isomers of the metal-metal bonded compound [(CO)Cl2Rh(mu-Ph(2)PBzIm)(2)PdCl]. (C) 2002 Elsevier Science B.V. All rights reserved.