methyl-phenyl-carbamic acid 4-(4-imidazol-1-yl-phenoxymethyl)-phenyl ester | 548770-71-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: methyl-phenyl-carbamic acid 4-(4-imidazol-1-yl-phenoxymethyl)-phenyl ester
• 英文别名: [4-[(4-imidazol-1-ylphenoxy)methyl]phenyl] N-methyl-N-phenylcarbamate
• CAS: 548770-71-4
• 化学式: C₂₄H₂₁N₃O₃
• 分子量: 399.449
• InChiKey: YURODRREXGBBKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  56.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
  申请人：——

  公开号：US20030166644A1

  公开（公告）日：2003-09-04

  Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.

  使用化合物抑制激素敏感性脂肪酶，包括这些化合物的药物组合物，使用这些化合物和组合物的治疗方法，以及新化合物。目前的化合物是激素敏感性脂肪酶的抑制剂，可能在治疗和/或预防需要降低激素敏感性脂肪酶活性的医学疾病中有用。
• [EN] PARA-SUBTITUTED PHENYL CARBAMATES AS INHIBITORS OF HORMONE SENSITIVE LIPASE<br/>[FR] CARBAMATES DE PHENYLE PARA-SUBSTITUES EN TANT QU'INHIBITEURS DE LA LIPASE HORMONO-SENSIBLE
  申请人：NOVO NORDISK AS

  公开号：WO2004111006A1

  公开（公告）日：2004-12-23

  Novel para-substituted phenyl carbamates, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to hormone sensitive lipase. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which modulation of the activity of hormone sensitive lipase is beneficial.

  对于取代苯基氨基甲酸酯的新型化合物，包括它们的药物组合物以及它们在治疗和/或预防与荷尔蒙敏感性脂肪酶相关的疾病和障碍方面的用途。更具体地说，这些化合物可用于治疗和/或预防在其中调节荷尔蒙敏感性脂肪酶活性有益的疾病和障碍。
• Use of compounds for decreasing activity of hormone-sensitive
  申请人：——

  公开号：US20030166690A1

  公开（公告）日：2003-09-04

  Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.

  使用化合物来抑制激素敏感性脂肪酶，包括这些化合物的制药组合物，使用这些化合物和组合物的治疗方法，以及新颖的化合物。这些化合物是激素敏感性脂肪酶的抑制剂，可用于治疗和/或预防需要降低激素敏感性脂肪酶活性的医学疾病。
• Substituted p-phenyl carbamates
  申请人：Vedso Per

  公开号：US20060148860A1

  公开（公告）日：2006-07-06

  Novel substituted p-phenyl carbamates, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to hormone sensitive lipase. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which modulation of the activity of hormone sensitive lipase is beneficial.

  小说替代p-苯基氨基甲酸酯，包括它们的制药组合物和在与激素敏感性脂肪酶相关的疾病和障碍的治疗和/或预防中的使用。更具体地说，这些化合物对于调节激素敏感性脂肪酶活性有益的疾病和障碍的治疗和/或预防是有用的。
• COMPOSITIONS FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE
  申请人：NOVO NORDISK A/S

  公开号：EP1458375A2

  公开（公告）日：2004-09-22