7-methoxy-1,2-dihydro-cyclopenta[a]naphthalen-3-one | 109219-51-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 7-methoxy-1,2-dihydro-cyclopenta[a]naphthalen-3-one
• 英文别名: 7-Methoxy-1,2-dihydro-cyclopenta[a]naphthalin-3-on；7-methoxy-1,2-dihydrocyclopenta[a]naphthalen-3-one
• CAS: 109219-51-4
• 化学式: C₁₄H₁₂O₂
• 分子量: 212.248
• InChiKey: LYFIXYHPQPWSIS-UHFFFAOYSA-N

物化性质

• 沸点：
  386.0±11.0 °C(Predicted)
• 密度：
  1.225±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.98
• 重原子数：
  16.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  7-methoxy-1,2-dihydro-cyclopenta[a]naphthalen-3-one 生成 7-methoxy-1,2-dihydro-cyclopenta[a]naphthalen-3-one semicarbazone
  参考文献：
  名称：

  Acupuncture and Clinical Hypnosis for Facial and Head and Neck Pain: A Single Crossover Comparison

  摘要：

  Despite their long histories, acupuncture and hypnosis have only recently been acknowledged as valuable by the medical establishment in the U.S. Few studies have used rigorous prospective measurement to evaluate the individual or relative merits of hypnosis and acupuncture in specific clinical settings.In this study, 25 patients with various head and neck pain were studied. Each had an initial assessment of their pain, as well as of their attitudes and expectations. All patients received acupuncture, followed by a reassessment of their pain. After a washout period they received another assessment of pain before and after hypnosis therapy. Preferences for therapy were sought following the hypnotic intervention.Both acupuncture and hypnosis were effective at relieving pain under these conditions. The average relief in pain reported was 4.2 units on a ten point scale, with hypnosis reducing pain by a mean of 4.8 units, compared to 3.7 for acupuncture (p = 0.26). Patient characteristics appeared to impact the effectiveness of treatment: patients with acute pain benefited most from acupuncture treatment, whereas patients with psychogenic pain were more likely to benefit from hypnosis. Patients with chronic pain had more variation in their results. Patients who received healing suggestions from a tape during a hypnotic trance benefited more than those who received no such suggestion, and acupuncture patients who were needle phobic benefited less than those who were not fearful of needles.This study demonstrates the benefits of well designed studies of the effectiveness of these alternative modalities. More work is needed to help practitioners identify which patients are most likely to benefit from these complementary therapies.

  DOI：

  10.1080/00029157.2001.10403469
• 作为产物：
  描述：

  (6-methoxy-[1]naphthylmethyl)-malonic acid 在 PPA 作用下， 170.0 ℃ 、1.47 kPa 条件下， 生成 7-methoxy-1,2-dihydro-cyclopenta[a]naphthalen-3-one
  参考文献：
  名称：

  Acupuncture and Clinical Hypnosis for Facial and Head and Neck Pain: A Single Crossover Comparison

  摘要：

  Despite their long histories, acupuncture and hypnosis have only recently been acknowledged as valuable by the medical establishment in the U.S. Few studies have used rigorous prospective measurement to evaluate the individual or relative merits of hypnosis and acupuncture in specific clinical settings.In this study, 25 patients with various head and neck pain were studied. Each had an initial assessment of their pain, as well as of their attitudes and expectations. All patients received acupuncture, followed by a reassessment of their pain. After a washout period they received another assessment of pain before and after hypnosis therapy. Preferences for therapy were sought following the hypnotic intervention.Both acupuncture and hypnosis were effective at relieving pain under these conditions. The average relief in pain reported was 4.2 units on a ten point scale, with hypnosis reducing pain by a mean of 4.8 units, compared to 3.7 for acupuncture (p = 0.26). Patient characteristics appeared to impact the effectiveness of treatment: patients with acute pain benefited most from acupuncture treatment, whereas patients with psychogenic pain were more likely to benefit from hypnosis. Patients with chronic pain had more variation in their results. Patients who received healing suggestions from a tape during a hypnotic trance benefited more than those who received no such suggestion, and acupuncture patients who were needle phobic benefited less than those who were not fearful of needles.This study demonstrates the benefits of well designed studies of the effectiveness of these alternative modalities. More work is needed to help practitioners identify which patients are most likely to benefit from these complementary therapies.

  DOI：

  10.1080/00029157.2001.10403469

文献信息

• Cowell; Mathieson, Journal of Pharmacy and Pharmacology, 1957, vol. 9, p. 549,553
  作者：Cowell、Mathieson

  DOI：——

  日期：——
• Intramolecular acylation. Part V. Preparation and ring closure of some methoxy-1-naphthyl-acetic, -propionic, -butyric, and -α-ethylglutaric acids
  作者：A. L. Green、D. H. Hey

  DOI：10.1039/jr9540004306

  日期：——
• CHATTERJEE, A.;RAYCHAUDHURI, S. R.;CHATTERJEE, S. K., TETRAHEDRON, 1981, 37, N 21, 3653-3660
  作者：CHATTERJEE, A.、RAYCHAUDHURI, S. R.、CHATTERJEE, S. K.

  DOI：——

  日期：——