N-cyclopropylmethyl-20,20-dimethylnorthevinone | 168421-15-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: N-cyclopropylmethyl-20,20-dimethylnorthevinone
• CAS: 168421-15-6
• 化学式: C₂₈H₃₅NO₄
• 分子量: 449.59
• InChiKey: QAQUBCPSIIVDER-VTNDKHKTSA-N

反应信息

• 作为反应物：
  描述：

  N-cyclopropylmethyl-20,20-dimethylnorthevinone 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 50.0 ℃ 、448.16 kPa 条件下， 反应 24.0h， 以91%的产率得到1-[(1S,2S,6R,14R,15R,16S)-5-(cyclopropylmethyl)-11,15-dimethoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-16-yl]-2-methylpropan-1-one
  参考文献：
  名称：

  Methylation of the enolates of thevinone and some analogues

  摘要：

  Branching has been introduced into various thevinone analogues by utilisation of both kinetic and thermodynamic enolates. No rearrangement was observed in the systems under study.

  DOI：

  10.1016/0040-4020(95)00553-k
• 作为产物：
  描述：

  N-cyclopropylmethyl-20-methylnorthevinone 、 碘甲烷 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 以66%的产率得到N-cyclopropylmethyl-20,20-dimethylnorthevinone
  参考文献：
  名称：

  Methylation of the enolates of thevinone and some analogues

  摘要：

  Branching has been introduced into various thevinone analogues by utilisation of both kinetic and thermodynamic enolates. No rearrangement was observed in the systems under study.

  DOI：

  10.1016/0040-4020(95)00553-k