2-(thiazolidin-3-yl)ethyl (E)-6-[1,3-dihydro-4-(3-(2-chlorophenyl)ureido)-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl]-4-methyl-4-hexenoate | 1238169-45-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: 2-(thiazolidin-3-yl)ethyl (E)-6-[1,3-dihydro-4-(3-(2-chlorophenyl)ureido)-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl]-4-methyl-4-hexenoate
• 英文别名: 2-(1,3-thiazolidin-3-yl)ethyl (E)-6-[4-[(2-chlorophenyl)carbamoylamino]-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl]-4-methylhex-4-enoate
• CAS: 1238169-45-3
• 化学式: C₂₉H₃₄ClN₃O₆S
• 分子量: 588.124
• InChiKey: IGVXYPLHOXTRSG-QGMBQPNBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  40
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  132
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] METABOLISM-MODULATING AGENTS AND USES THEREFOR<br/>[FR] AGENTS DE MODULATION DU MÉTABOLISME ET UTILISATIONS ASSOCIÉES
  申请人：UNIV QUEENSLAND

  公开号：WO2006017896A1

  公开（公告）日：2006-02-23

  The present invention is directed to methods and agents for modulating adipogenesis. More particularly, the present invention relates to molecules that modulate the level or functional activity of inosine-5' monophosphate dehydrogenase (IMPDH) and to their use in modulating the accumulation of lipids in adipocytes and/or the differentiation of preadipocytes to adipocytes for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma, lipomatosis, cachexia or lipodystrophy or the loss of adipose tissue in trauma or atrophic conditions.

  本发明旨在提供调节脂肪生成的方法和试剂。更具体地，本发明涉及能够调节次黄嘌呤-5'一磷酸脱氢酶（IMPDH）的水平或功能活性的分子，以及它们在调节脂肪细胞中脂质的积累和/或脂肪细胞前体分化为脂肪细胞方面的作用，从而用于治疗或预防与脂肪量相关的疾病，包括但不限于肥胖症、脂肪瘤、脂肪瘤病、恶病质或脂肪营养不良，或由于创伤或萎缩性条件导致的脂肪组织损失。
• METABOLISM-MODULATING AGENTS AND USES THEREFOR
  申请人：THE UNIVERSITY OF QUEENSLAND

  公开号：EP1786415A1

  公开（公告）日：2007-05-23