7Z,13Z,16Z,19Z-docosatetraenoic acid | 60813-11-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7Z,13Z,16Z,19Z-docosatetraenoic acid
• 英文别名: (7Z,13Z,16Z,19Z)-docosa-7,13,16,19-tetraenoic acid
• CAS: 60813-11-8
• 化学式: C₂₂H₃₆O₂
• 分子量: 332.527
• InChiKey: UOFNKTZBIIBWQR-OUJQXAOTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  24
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7Z,13Z,16Z,19Z-docosatetraenoic acid 在 lithium aluminium deuteride 、 硼氘化钠 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以96%的产率得到(7Z,10Z,13Z,16Z,19Z)-docosa-7,10,13,16,19-pentaen-1-ol-d2
  参考文献：
  名称：

  Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids

  摘要：

  First syntheses of a deuterium-labeled very long C34-containing polyunsaturated fatty acid, 34:5n5, and three other unlabeled very long chain C30-32 containing polyunsaturated fatty acids are reported. These syntheses were achieved by coupling chemically modified C22- and C20-containing polyunsaturated fatty acids with carbanions derived from arylalkyl sulfones, followed by sodium amalgam-mediated desulfonylation. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.139

文献信息

• Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids
  作者：Ghulam M. Maharvi、Albert O. Edwards、Abdul H. Fauq

  DOI：10.1016/j.tetlet.2010.09.139

  日期：2010.12

  First syntheses of a deuterium-labeled very long C34-containing polyunsaturated fatty acid, 34:5n5, and three other unlabeled very long chain C30-32 containing polyunsaturated fatty acids are reported. These syntheses were achieved by coupling chemically modified C22- and C20-containing polyunsaturated fatty acids with carbanions derived from arylalkyl sulfones, followed by sodium amalgam-mediated desulfonylation. (C) 2010 Elsevier Ltd. All rights reserved.