1-(4-tert-Butyl-phenyl)-6-chloro-3-hydroxy-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester | 911842-77-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-(4-tert-Butyl-phenyl)-6-chloro-3-hydroxy-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester
• CAS: 911842-77-8
• 化学式: C₂₀H₂₁ClN₂O₃
• 分子量: 372.851
• InChiKey: FLRHVVWAPYWWKM-UHFFFAOYSA-N

物化性质

• 沸点：
  437.8±45.0 °C(Predicted)
• 密度：
  1.25±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.86
• 重原子数：
  26.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  64.35
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  1-(4-tert-Butyl-phenyl)-6-chloro-3-hydroxy-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester 在 sodium hydroxide 、 copper diacetate 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 32.0h， 生成 1-(4-tert-Butyl-phenyl)-6-chloro-3-(3-trifluoromethyl-phenoxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid
  参考文献：
  名称：

  Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists

  摘要：

  A series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPAR gamma modulators. Their chemical synthesis and in vitro activities are discussed. Compound 5 was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.08.002
• 作为产物：
  描述：

  ethyl (4-(tert-butyl)phenyl)glycinate 在 sodium ethanolate 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 8.0h， 生成 1-(4-tert-Butyl-phenyl)-6-chloro-3-hydroxy-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester
  参考文献：
  名称：

  Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists

  摘要：

  A series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPAR gamma modulators. Their chemical synthesis and in vitro activities are discussed. Compound 5 was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.08.002