2-Methyl-4,5-bis-imidazol | 30450-41-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Methyl-4,5-bis-imidazol
• 英文别名: 4,5-bis-(4-chloro-phenyl)-2-methyl-1H-imidazole；4,5-bis(4-chlorophenyl)-2-methyl-1H-imidazole
• CAS: 30450-41-0
• 化学式: C₁₆H₁₂Cl₂N₂
• 分子量: 303.191
• InChiKey: IIZZQXAUYMDYGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] SUBSTITUTED IMIDAZOLES AS CANNABINOID RECEPTOR MODULATORS<br/>[FR] IMIDAZOLES SUBSTITUES SERVANT DE MODULATEURS DE RECEPTEURS DE CANNABINOIDES
  申请人：MERCK & CO INC

  公开号：WO2003007887A2

  公开（公告）日：2003-01-30

  The use of compounds of the present invention as antagonists and/or inverse agonists of the Cannabinoid-1 (CB1)receptor particularly in the treatment, prevention and suppression of diseases mediated by the Cannabinoid-1 (CB1) receptor. The invention is concerned with the use of these novel compounds to selectively antagonize the Cannabinoid-1 (CB1) receptor. As such, compounds of the present invention are useful as psychotropic drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith. Novel compounds of structural formula (I) are also claimed.