4-(2,3-二甲基苄基)-1H-咪唑盐酸盐水合物 | 90038-00-9

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(2,3-二甲基苄基)-1H-咪唑盐酸盐水合物
• 中文别名: 美托咪定杂质14
• 英文名称: detomidine hydrochloride monohydrate
• 英文别名: 5-[(2,3-dimethylphenyl)methyl]-1H-imidazole;hydrate;hydrochloride
• CAS: 90038-00-9
• 化学式: C₁₂H₁₄N₂*ClH*H₂O
• 分子量: 240.733
• InChiKey: IQBSKEIWIRTMOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.21
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.7
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  (3-Benzylimidazol-4-yl)-(2,3-dimethylphenyl)methanol;hydrochloride 在 盐酸 、 palladium on activated charcoal 、 氢气 作用下， 以 水 为溶剂， 生成 4-(2,3-二甲基苄基)-1H-咪唑盐酸盐水合物
  参考文献：
  名称：

  [EN] DETOMIDINE HYDROCHLORIDE MONOHYDRATE
  [FR] MONOHYDRATE DE CHLORHYDRATE DE DÉTOMIDINE

  摘要：

  The present invention relates to detomidine hydrochloride monohydrate, a method for the production of the same and to the use of the same as a medicament, that is for use as anesthetic, analgesic, muscle relaxant, sedative and any other condition susceptible to treatment with an alpha2- adrenoreceptor agonist in a mammal. Detomidine hydrochloride monohydrate described herein represents the pure monohydrate form which additionally shows a high purity reflected the very low content of impurities and especially residual solvents. Correspondingly, detomidine hydrochloride monohydrate described herein, shows a very high storage stability which is useful for the production of pharmaceutical compositions for the treatment of pathological conditions.

  公开号：

  WO2021037755A1

文献信息

• DETOMIDINE HYDROCHLORIDE MONOHYDRATE
  申请人：Sachse, Andreas

  公开号：EP3782989A1

  公开（公告）日：2021-02-24

  The present invention relates to detomidine hydrochloride monohydrate, a method for the production of the same and to the use of the same as a medicament, that is for use as anesthetic, analgesic, muscle relaxant, sedative and any other condition susceptible to treatment with an alpha2-adrenoreceptor agonist in a mammal. Detomidine hydrochloride monohydrate described herein represents the pure monohydrate form which additionally shows a high purity reflected the very low content of impurities and especially residual solvents. Correspondingly, detomidine hydrochloride monohydrate described herein, shows a very high storage stability which is useful for the production of pharmaceutical compositions for the treatment of pathological conditions.

  本发明涉及盐酸地托咪定一水合物、盐酸地托咪定一水合物的生产方法以及盐酸地托咪定一水合物的药物用途，盐酸地托咪定一水合物可用作哺乳动物的麻醉剂、镇痛剂、肌肉松弛剂、镇静剂以及任何其他可接受α2-肾上腺素受体激动剂治疗的病症。 本文所述的盐酸地托咪定一水合物是纯净的一水合物，其高纯度反映了杂质，特别是残留溶剂的含量极低。相应地，本文所述的盐酸地托咪定一水合物显示出极高的储存稳定性，可用于生产治疗病症的药物组合物。
• Methods of treating pruritus
  申请人：Clexio Biosciences Ltd.

  公开号：US11185532B2

  公开（公告）日：2021-11-30

  The present disclosure related to methods of treating pruritus in a subject by topically administering detomidine, or a pharmaceutically acceptable salt thereof, to the subject.

  本公开涉及通过对受试者局部施用地托咪定或其药学上可接受的盐来治疗受试者瘙痒症的方法。
• [EN] PURIFIED CRYSTALLINE DETOMIDINE HYDROCHLORIDE MONOHYDRATE, ANHYDRATE AND FREE BASE WITH LOW AMOUNTS OF ISO-DETOMIDINE AND OTHER IMPURITIES BY RECRYSTALLISATION IN WATER<br/>[FR] CHLORHYDRATE DE DÉTOMIDINE MONOHYDRATÉ SOUS FORME CRISTALLINE PURIFIÉE, ANHYDRATE DE DÉTOMIDINE ET BASE LIBRE DE DÉTOMIDINE PRÉSENTANT DE FAIBLES QUANTITÉS D'ISO-DÉTOMIDINE ET D'AUTRES IMPURETÉS, OBTENUS PAR RECRISTALLISATION DANS L'EAU
  申请人：CLEXIO BIOSCIENCES LTD

  公开号：WO2020016827A4

  公开（公告）日：2020-03-19
• Methods Of Treating Pruritus
  申请人：Clexio Biosciences Ltd.

  公开号：US20200345698A1

  公开（公告）日：2020-11-05

  The present disclosure related to methods of treating pruritus in a subject by topically administering detomidine, or a pharmaceutically acceptable salt thereof, to the subject.
• TOPICAL DETOMIDINE FORMULATIONS
  申请人：Clexio Biosciences Ltd.

  公开号：US20210220336A1

  公开（公告）日：2021-07-22

  The present disclosure relates to a purified detomidine HCl pharmaceutical product and to methods of preparation, validation of pharmaceutically acceptable product and use thereof.