| 946157-74-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• CAS: 946157-74-0
• 化学式: C₂₁H₂₁NO₄
• 分子量: 351.402
• InChiKey: XEBOOWNANCETNY-OKYOBFRVSA-N

反应信息

• 作为反应物：
  描述：

  在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 以99%的产率得到(3aS,4R,9aS)-1-oxo-3a,4,9,9a-tetrahydro-3H-benzo[f][2]benzofuran-4-carboxylic acid
  参考文献：
  名称：

  Himbacine derived thrombin receptor antagonists: Discovery of a new tricyclic core

  摘要：

  The synthesis and biological activity of a novel series of thrombin receptor antagonists is described. This series of compounds showed excellent in vitro and in vivo potency. The most potent compound 40 had an IC50 of 7.6 nM and showed robust inhibition of platelet aggregation in a cynomolgus monkey model after oral administration. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.04.061
• 作为产物：
  描述：

  (3aR,4S,9aR)-1-Oxo-1,3,3a,4,9,9a-hexahydro-naphtho[2,3-c]furan-4-carboxylic acid 在 草酰氯 、 TEA 、 N,N-二甲基甲酰胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Himbacine derived thrombin receptor antagonists: Discovery of a new tricyclic core

  摘要：

  The synthesis and biological activity of a novel series of thrombin receptor antagonists is described. This series of compounds showed excellent in vitro and in vivo potency. The most potent compound 40 had an IC50 of 7.6 nM and showed robust inhibition of platelet aggregation in a cynomolgus monkey model after oral administration. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.04.061