(2R,3R,6R)-1-(tert-butoxycarbonyl)-5-dodecyl-3-hydroxy-2-vinylpiperidine | 201685-54-3

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: (2R,3R,6R)-1-(tert-butoxycarbonyl)-5-dodecyl-3-hydroxy-2-vinylpiperidine
• CAS: 201685-54-3
• 化学式: C₂₄H₄₅NO₃
• 分子量: 395.626
• InChiKey: WBHHHJFILDEJQR-YPAWHYETSA-N

反应信息

• 作为反应物：
  描述：

  (2R,3R,6R)-1-(tert-butoxycarbonyl)-5-dodecyl-3-hydroxy-2-vinylpiperidine 在 sodium tetrahydroborate 、 对甲苯磺酸 、 臭氧 作用下， 以 二氯甲烷 为溶剂， 生成 (1R,6R,8R)-7-(tert-butoxycarbonyl)-3,3-dimethyl-2,4-dioxa-8-dodecyl-7-azabicyclo[4.4.0]decane
  参考文献：
  名称：

  Asymmetric total syntheses of hydroxylated piperidine alkaloids via the intramolecular reaction of γ-aminoallylstannane with aldehyde

  摘要：

  Asymmetric total syntheses of (+)-desoxoprosopinine and (-)-desoxoprosophylline were accomplished using L-glutamic acid as the chiral source, in which the intramolecular reaction of a gamma-aminoallylstannane with an aldehyde was used as a key step. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(97)00563-6
• 作为产物：
  描述：

  [(R)-1-(3-Oxo-propyl)-tridecyl]-((Z)-3-tributylstannanyl-propenyl)-carbamic acid tert-butyl ester 在 三氟乙酸 作用下， 以 甲苯 为溶剂， 反应 4.5h， 以72%的产率得到(2R,3R,6R)-1-(tert-butoxycarbonyl)-5-dodecyl-3-hydroxy-2-vinylpiperidine
  参考文献：
  名称：

  Asymmetric total syntheses of hydroxylated piperidine alkaloids via the intramolecular reaction of γ-aminoallylstannane with aldehyde

  摘要：

  Asymmetric total syntheses of (+)-desoxoprosopinine and (-)-desoxoprosophylline were accomplished using L-glutamic acid as the chiral source, in which the intramolecular reaction of a gamma-aminoallylstannane with an aldehyde was used as a key step. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(97)00563-6