1-{3-[3-(benzothiazol-2-ylaminomethyl)-4-trifluoromethyl-phenyl]-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl}-3-pyrrolidin-1-yl-propan-2-ol | 1072963-89-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-{3-[3-(benzothiazol-2-ylaminomethyl)-4-trifluoromethyl-phenyl]-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl}-3-pyrrolidin-1-yl-propan-2-ol
• 英文别名: 1-[3-[3-[(1,3-benzothiazol-2-ylamino)methyl]-4-(trifluoromethyl)phenyl]-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-3-pyrrolidin-1-ylpropan-2-ol
• CAS: 1072963-89-3
• 化学式: C₂₉H₃₃F₃N₆O₃S₂
• 分子量: 634.747
• InChiKey: IDKSWZKRCHSRHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  43
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  140
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• BICYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S
  申请人：Allen Darin

  公开号：US20080269241A1

  公开（公告）日：2008-10-30

  Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.

  本文描述了双环氨基丙基四氢吡唑吡啶化合物，可用作蛋白酶S的调节剂。这些化合物可用于制备药物组合物和治疗疾病状态、障碍和由蛋白酶S活性介导的疾病，如牛皮癣、疼痛、多发性硬化症、动脉粥样硬化和类风湿性关节炎的方法。
• MONOCYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S
  申请人：Allen Darin

  公开号：US20090118274A1

  公开（公告）日：2009-05-07

  Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.

  本文描述了单环氨基丙基四氢吡唑吡啶化合物，其可用作蛋白酶S调节剂。这些化合物可用于制备药物组合物和治疗由蛋白酶S活性介导的疾病状态、紊乱和病况，例如银屑病、疼痛、多发性硬化症、动脉硬化和类风湿性关节炎的方法。