2-{3-cyano-4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}nicotinic acid | 1033602-09-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-{3-cyano-4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}nicotinic acid
• 英文别名: 2-[3-Cyano-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]pyridine-3-carboxylic acid
• CAS: 1033602-09-3
• 化学式: C₂₅H₁₉N₃O₄
• 分子量: 425.444
• InChiKey: SHUXIEJIESUJQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• 2-PHENYLNICOTINIC ACID DERIVATIVE
  申请人：Menjo Nobuo

  公开号：US20100004459A1

  公开（公告）日：2010-01-07

  The present invention is to provide the compounds useful as a treating or preventing agent for gout and hyperuricemia which are 2-phenylnicotinic acid derivatives having a uric acid lowering action due to an excellent xanthine oxidase inhibitory action. Since the 2-phenylnicotinic acid derivatives of the present invention exhibit a uric acid lowering action due to an excellent xanthine oxidase inhibitory action and also hypolipemic action, their utility is very high as a treating or preventive agent for gout and hyperuricemia which are often accompanied by hyperlipemia as a complication.

  本发明提供了一种化合物，它是2-苯基烟酸衍生物，具有出色的黄嘌呤氧化酶抑制作用，可用作痛风和高尿酸血症的治疗或预防剂。由于本发明的2-苯基烟酸衍生物表现出出色的黄嘌呤氧化酶抑制作用和降脂作用，因此它们作为治疗或预防痛风和高尿酸血症的药物，其实用价值非常高，因为这些疾病通常伴随着高脂血症的并发症。