N-hydroxy-4-(2-phenylimidazo[2,1-b][1,3]benzothiazol-6-yl)sulfonyloxane-4-carboxamide | 701271-90-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-hydroxy-4-(2-phenylimidazo[2,1-b][1,3]benzothiazol-6-yl)sulfonyloxane-4-carboxamide
• CAS: 701271-90-1
• 化学式: C₂₁H₁₉N₃O₅S₂
• 分子量: 457.531
• InChiKey: HSZTUFBMCRRTHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  147
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] HETEROARYLSULFONYLMETHYL HYDROXAMIC ACIDS AND AMIDES AND THEIR USE AS PROTEASE INHIBITORS<br/>[FR] ACIDES ET AMIDES HETEROARYLSULFONYLMETHYL HYDROXAMIQUES ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE PROTEASES
  申请人：PHARMACIA CORP

  公开号：WO2004048368A2

  公开（公告）日：2004-06-10

  This invention is directed generally to heteroarylsulfonylmethyl hydroxamic acids and amides that, inter alia, tend to inhibit protease activity, particularly matrix metalloproteinase (also known as 'matrix metalloprotease' or 'MMP') activity and/or aggrecanase activity. This invention also is directed to compositions of such compounds; intermediates for the syntheses of such compounds; methods for making such compounds; and methods for treating conditions associated with MMP, tumor necrosis factors (or 'TNFs'), and/or aggrecanase activity, particularly pathological conditions.