3,4,5-Trimethyl-1-propargyl-pyrazol | 27258-03-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3,4,5-Trimethyl-1-propargyl-pyrazol
• 英文别名: 3,4,5-trimethyl-1-prop-2-ynyl-1H-pyrazole；3,4,5-trimethyl-1-(prop-2-yn-1-yl)-1H-pyrazole；3,4,5-trimethyl-1-prop-2-ynylpyrazole
• CAS: 27258-03-3
• 化学式: C₉H₁₂N₂
• mdl: MFCD14638464
• 分子量: 148.208
• InChiKey: WJNCFXQQBCOBRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.444
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF DISEASES
  申请人：Bunnage Mark Edward

  公开号：US20130196952A1

  公开（公告）日：2013-08-01

  The invention relates to compounds of Formula (1) and to processes for the preparation of intermediates used in the preparation of compositions containing and the uses of such derivatives. The compounds according to the present invention are useful in numerous diseases in which ALK protein is involved or in which inhibition of ALK activity may induce benefit, especially for the treatment of cancer mediated by a mutated EML4-ALK fusion protein.

  本发明涉及式（1）的化合物，以及用于制备含有这些衍生物的组合物的中间体的制备过程和使用。根据本发明的化合物在许多与ALK蛋白有关或抑制ALK活性可能产生益处的疾病中非常有用，特别是用于治疗由突变的EML4-ALK融合蛋白介导的癌症。
• Pyrazole compounds as nitrification inhibitors
  申请人：BASF SE

  公开号：US10556844B2

  公开（公告）日：2020-02-11

  Pyrazole derivatives as nitrification inhibitors are described herein.

  本文介绍了作为硝化抑制剂的吡唑衍生物。
• PYRAZOLE COMPOUNDS AS NITRIFICATION INHIBITORS
  申请人：BASF SE

  公开号：US20180016199A1

  公开（公告）日：2018-01-18

  Pyrazole derivatives as nitrification inhibitors are described herein.