5-Isopropyl-6-mercapto-1H-pyrimidin-2-one | 138913-96-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-Isopropyl-6-mercapto-1H-pyrimidin-2-one
• 英文别名: 5-Isopropyl-4-thiouracil；5-propan-2-yl-4-sulfanylidene-1H-pyrimidin-2-one
• CAS: 138913-96-9
• 化学式: C₇H₁₀N₂OS
• 分子量: 170.235
• InChiKey: IDDFYZWBYKKAKE-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  5-Isopropyl-6-mercapto-1H-pyrimidin-2-one 在 1-氧杂-2-氮杂螺[2.5]辛烷 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 以82%的产率得到6-Aminosulfanyl-5-isopropyl-1H-pyrimidin-2-one
  参考文献：
  名称：

  N-Unsubstituted Sulfenamides by Electrophilic Amination of mercapto compounds

  摘要：

  Potential mercapto compounds derived from electron deficient heterocycles as 2- and 4-thiouracils, pyridines and pyridine-1-oxide are aminated by the oxaziridine 1 to new sulfenamides (6, 9, 11 and 15 or the isothiazolo-pyridine 14) which add to phenylisocyanates forming sulfenylureas (7, 10, 12 and 16). Several other mercapto compounds gave disulfides. Attempts of oxidation of the sulfenamides and the sulfenylureas were unsuccessful. The methylmercapto compound 19 after amination was hydrolyzed to the sulfoxide 20.

  DOI：

  10.1002/prac.19973390129

文献信息

• CYCLIC DI-NUCLEOTIDES AS STIMULATOR OF INTERFERON GENES MODULATORS
  申请人：Beijing Xuanyi PharmaSciences Co., Ltd.

  公开号：US20200331957A1

  公开（公告）日：2020-10-22

  The present disclosure relates to a compound of formulae (I) or (II), or a pharmaceutically acceptable salt, a solvate, a hydrate thereof, a pharmaceutical composition comprising a compound of formulae (I) or (II), and use thereof, wherein various Markush groups are as described herein.