<1-15N>-2,4-dinitroaniline | 71018-49-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: <1-15N>-2,4-dinitroaniline
• 英文别名: 2,4-Dinitro-<15N>anilin；2,4-dinitro-[¹⁵N]aniline
• CAS: 71018-49-0
• 化学式: C₆H₅N₃O₄
• 分子量: 184.117
• InChiKey: LXQOQPGNCGEELI-CDYZYAPPSA-N

反应信息

• 作为产物：
  描述：

  3-N-(2,4-dinitrophenyl)-6-chloro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-2,3-dihydropurin-2-one 在 15N-氨 作用下， 反应 12.0h， 以26 mg的产率得到<1-15N>-2,4-dinitroaniline
  参考文献：
  名称：

  6-Chloroxanthosine, a Useful Intermediate for the Efficient Syntheses of [6-¹⁵N]-Isoguanosine, Isoinosine and Other Purine Nucleoside Analogues

  摘要：

  6-Chloroxanthosine 1, when activated towards nucleophilic displacement at the 6-C position by conversion into the corresponding 3-N-(2,4-dinitrophenyl) derivative 4, reacted with aq. (NH3)-N-15 to afford [6-N-15]-isoguanosine 3b in 81% overall yield. Catalytic hydrogenation (Pd/C) of 1 led in 60% yield to isoinosine 8; alternatively, this could be obtained in 88% overall yield through alkaline hydrolysis of triphenylphosphonium salt 6, synthesized from 1 by reaction with PPh(3). The reactivity of 1 was further explored by treating it with primary and secondary amines: the 6-N propylamino and the 6-N piperidinyl derivatives (5a and 5b, respectively) could thus both be prepared in more than 90% yield.

  DOI：

  10.1080/07328319708002532