2,4-diphenyl-3-benzyl-3H-1-benzazepine | 1620204-66-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 2,4-diphenyl-3-benzyl-3H-1-benzazepine
• CAS: 1620204-66-1
• 化学式: C₂₉H₂₃N
• 分子量: 385.508
• InChiKey: COZJDAKSDYBSSV-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  氯化苄 、 2,4-diphenyl-3H-1-benzazepine 在 六甲基磷酰三胺 、 双(三甲基硅烷基)氨基钾 作用下， 以 四氢呋喃 为溶剂， 反应 0.59h， 以33%的产率得到2,4-diphenyl-1-benzyl-1H-1-benzazepine
  参考文献：
  名称：

  Regioselective alkylation reactions of 2,4-diphenyl-3H-1-benzazepine give either 3-alkyl-3H-1-benzazepines or 1-alkyl-1H-1-benzazepines

  摘要：

  2,4-Diphenyl-3H-1-benzazepine is deprotonated with either LDA or KHMDS. The resulting anion is alkylated with alkyl halides or MeOTs, giving either products of alkylation at C3, or at N, or a mixture of both. The regioselectivity depends on the base, presence of the complexing agent HMPA, and the leaving group of the allcylating agent. Using Mel as alkylating agent gives exclusively the C3-methylated product, while using MeOTs gives exclusively the N-methylated product. The N-allcylated products show evidence of stereodynamic behavior in their NMR spectra. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.05.128