3-[(5-hydroxy-1-phenyl-1H-pyrazole-3-carbonyl)-amino]-3-p-tolyl-propionic acid | 1318781-71-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[(5-hydroxy-1-phenyl-1H-pyrazole-3-carbonyl)-amino]-3-p-tolyl-propionic acid
• CAS: 1318781-71-3
• 化学式: C₂₀H₁₉N₃O₄
• 分子量: 365.389
• InChiKey: QBMQPPYBALNMMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.83
• 重原子数：
  27.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  104.45
• 氢给体数：
  3.0
• 氢受体数：
  5.0

文献信息

• Intermediates for the synthesis of oxygen-substituted 3-heteroaroylamino-propionic acid derivatives
  申请人：SANOFI

  公开号：EP2826772A1

  公开（公告）日：2015-01-21

  The present invention relates to synthesis precursors useful for the preparation of compounds of the formula I, wherein A, D, E, G, R10, R30, R40, R50 and R60 have the meanings indicated in the description, which in turn are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example.

  本发明涉及用于制备式 I 化合物的合成前体、 其中 A、D、E、G、R10、R30、R40、R50 和 R60 的含义如说明书所示，它们是有价值的药物活性化合物。它们是蛋白酶 cathepsin A 的抑制剂，可用于治疗动脉粥样硬化、心力衰竭、肾病、肝病或炎症等疾病。
• OXYGEN-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
  申请人：SANOFI

  公开号：EP2528902B1

  公开（公告）日：2014-11-12
• [EN] USE OF SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AS PHARMACEUTICALS FOR PREVENTION/TREATMENT OF ATRIAL FIBRILLATION<br/>[FR] UTILISATION DE DÉRIVÉS SUBSTITUÉS DE L'ACIDE 3-HÉTÉROAROYLAMINO-PROPIONIQUE EN TANT QUE PRODUITS PHARMACEUTIQUES DESTINÉS À LA PRÉVENTION/AU TRAITEMENT DE LA FIBRILLATION AURICULAIRE
  申请人：SANOFI SA

  公开号：WO2014053533A1

  公开（公告）日：2014-04-10

  The present invention relates to the use of compounds of the formula (I) for the treatment/prevention of atrial fibrillation, wherein A, D, E, G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims. They are inhibitors of the protease cathepsin A.