1,2,3,6,7,8,9,10-octahydrocyclohepta[e]inden-4-ol | 1415667-68-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 1,2,3,6,7,8,9,10-octahydrocyclohepta[e]inden-4-ol
• 英文别名: 1,2,3,6,7,8,9,10-Octahydrocyclohepta[e]inden-4-ol
• CAS: 1415667-68-3
• 化学式: C₁₄H₁₈O
• 分子量: 202.296
• InChiKey: BDGGCTGCVXPGSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  benzyl(10-((tert-butyldimethylsilyl)oxy)-1,2,3,6,7,8,9,10-octahydrocyclohepta[e]inden-4-yl)dimethylsilane 在 四丁基氟化铵 、 双氧水 、 potassium hydrogencarbonate 、 zinc(II) chloride 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 21.0h， 生成 1,2,3,6,7,8,9,10-octahydrocyclohepta[e]inden-4-ol
  参考文献：
  名称：

  Metal-Catalyzed Syntheses of Abridged CDE Rings of Rubriflordilactones A and B

  摘要：

  The development of complementary palladium- and cobalt-catalyzed approaches to tricyclic arylsilanes suitable for elaboration into the CDE ring systems of rubriflordilactones A and B is reported. Microwave conditions are required to effect a cobalt-catalyzed triyne cyclotrimerization, which critically depends on the substitution pattern of the triyne termini. Mild conditions to elaborate these arylsilanes to the CDE cores of the natural products are described.

  DOI：

  10.1021/ol303041j

文献信息

• Metal-Catalyzed Syntheses of Abridged CDE Rings of Rubriflordilactones A and B
  作者：Shermin S. Goh、Hannah Baars、Birgit Gockel、Edward A. Anderson

  DOI：10.1021/ol303041j

  日期：2012.12.21

  The development of complementary palladium- and cobalt-catalyzed approaches to tricyclic arylsilanes suitable for elaboration into the CDE ring systems of rubriflordilactones A and B is reported. Microwave conditions are required to effect a cobalt-catalyzed triyne cyclotrimerization, which critically depends on the substitution pattern of the triyne termini. Mild conditions to elaborate these arylsilanes to the CDE cores of the natural products are described.