4-(4,5-dimethyl-1H-imidazol-2-yl)-2,6-dimethoxy-phenol | 20496-68-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(4,5-dimethyl-1H-imidazol-2-yl)-2,6-dimethoxy-phenol
• 英文别名: 4-(4,5-dimethyl-1H-imidazol-2-yl)-2,6-dimethoxyphenol
• CAS: 20496-68-8
• 化学式: C₁₃H₁₆N₂O₃
• 分子量: 248.282
• InChiKey: SVNNUCIFQDTAQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] SMALL MOLECULE NEUTRAL SPHINGOMYELINASE 2 (NSMASE2) INHIBITORS<br/>[FR] INHIBITEURS DE LA SPHINGOMYÉLINASE NEUTRE DE TYPE 2 À PETITES MOLÉCULES (NSMASE2)
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2020160148A1

  公开（公告）日：2020-08-06

  Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) and their use for treating neurodegenerative diseases, such as, neurodegenerative diseases associated with high levels of ceramide, including, but not limited to Alzheimer's disease (AD), HIV-associated neurocognitive disorder (HAND), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), and, in other aspects, for treating cancer or HIV-1, are provided.

  小分子抑制剂中和神经鞘磷脂酶2（nSMase2）及其用于治疗神经退行性疾病，如与高水平神经鞘磷脂有关的神经退行性疾病，包括但不限于阿尔茨海默病（AD）、艾滋病相关神经认知障碍（HAND）、多发性硬化（MS）和肌萎缩侧索硬化（ALS），以及在其他方面，用于治疗癌症或HIV-1。
• SMALL MOLECULE NEUTRAL SPHINGOMYELINASE 2 (NSMASE2) INHIBITORS
  申请人：The Johns Hopkins University

  公开号：EP3917530A1

  公开（公告）日：2021-12-08
• SMALL MOLECULE NEUTRAL SPHINGOMYELINASE 2 (nSMase2) INHIBITORS
  申请人：The Johns Hopkins University

  公开号：US20220119374A1

  公开（公告）日：2022-04-21

  Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) and their use for treating neurodegenerative diseases, such as, neurodegenerative diseases associated with high levels of ceramide, including, but not limited to Alzheimer's disease (AD), HIV-associated neurocognitive disorder (HAND), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), and, in other aspects, for treating cancer or HIV-1, are provided.