(S)-(-)-N-(2-cyclohexyl-2-(4-methoxyphenyl)ethyl)methanesulfonamide | 1312680-98-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (S)-(-)-N-(2-cyclohexyl-2-(4-methoxyphenyl)ethyl)methanesulfonamide
• 英文别名: N-[(2S)-2-cyclohexyl-2-(4-methoxyphenyl)ethyl]methanesulfonamide
• CAS: 1312680-98-0
• 化学式: C₁₆H₂₅NO₃S
• 分子量: 311.445
• InChiKey: OIPBXZXXZXYKHR-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  63.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 生成 (S)-(-)-N-(2-cyclohexyl-2-(4-methoxyphenyl)ethyl)methanesulfonamide
  参考文献：
  名称：

  Catalytic Asymmetric C–H Insertions of Rhodium(II) Azavinyl Carbenes

  摘要：

  A highly efficient enantioselective C-H insertion of azavinyl carbenes into unactivated alkanes has been developed. These transition metal carbenes are directly generated from readily available and stable 1-sulfonyl-1,2,3-triazoles in the presence of chiral Rh(II) carboxylates and are used for C-H functionalization of alkanes to access a variety of beta-chiral sulfonamides.

  DOI：

  10.1021/ja202969z

文献信息

• Catalytic Asymmetric C–H Insertions of Rhodium(II) Azavinyl Carbenes
  作者：Stepan Chuprakov、Jamal A. Malik、Mikhail Zibinsky、Valery V. Fokin

  DOI：10.1021/ja202969z

  日期：2011.7.13

  A highly efficient enantioselective C-H insertion of azavinyl carbenes into unactivated alkanes has been developed. These transition metal carbenes are directly generated from readily available and stable 1-sulfonyl-1,2,3-triazoles in the presence of chiral Rh(II) carboxylates and are used for C-H functionalization of alkanes to access a variety of beta-chiral sulfonamides.