1-[Fluoro(methylsulfonyl)methyl]-4-methoxybenzene | 1415115-31-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[Fluoro(methylsulfonyl)methyl]-4-methoxybenzene
• 英文别名: 1-[fluoro(methylsulfonyl)methyl]-4-methoxybenzene
• CAS: 1415115-31-9
• 化学式: C₉H₁₁FO₃S
• 分子量: 218.249
• InChiKey: OLXYADVSIIWCQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-[Fluoro-(4-methoxyphenyl)methyl]sulfonylpyridine 、 碘甲烷 在 2-甲基-2-丙硫醇钠盐 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.5h， 以85%的产率得到1-[Fluoro(methylsulfonyl)methyl]-4-methoxybenzene
  参考文献：
  名称：

  Copper-Mediated Fluoroalkylation of Aryl Iodides Enables Facile Access to Diverse Fluorinated Compounds: The Important Role of the (2-Pyridyl)sulfonyl Group

  摘要：

  The (2-pyridyl)sulfonyl group was found to be a multifunctional group in the preparation of structurally diverse fluorinated products. It not only facilitates the copper-mediated (or catalyzed) cross-coupling reaction between a-fluoro sulfone 4a and aryl iodides, but also enables further transformations of the coupling products 2.

  DOI：

  10.1021/ol3029737

文献信息

• Copper-Mediated Fluoroalkylation of Aryl Iodides Enables Facile Access to Diverse Fluorinated Compounds: The Important Role of the (2-Pyridyl)sulfonyl Group
  作者：Yanchuan Zhao、Bing Gao、Chuanfa Ni、Jinbo Hu

  DOI：10.1021/ol3029737

  日期：2012.12.7

  The (2-pyridyl)sulfonyl group was found to be a multifunctional group in the preparation of structurally diverse fluorinated products. It not only facilitates the copper-mediated (or catalyzed) cross-coupling reaction between a-fluoro sulfone 4a and aryl iodides, but also enables further transformations of the coupling products 2.