2-(3-Acetamidopropanamido)acetic acid | 16882-75-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: 2-(3-Acetamidopropanamido)acetic acid
• 英文别名: 2-(3-acetamidopropanoylamino)acetic acid
• CAS: 16882-75-0
• 化学式: C₇H₁₂N₂O₄
• 分子量: 188.18
• InChiKey: FJXTZKHLVGWMMM-UHFFFAOYSA-N

物化性质

• 沸点：
  594.8±35.0 °C(Predicted)
• 密度：
  1.249±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Multi-Arm Polymeric Alkanoate Conjugates
  申请人：Kozlowski Antoni

  公开号：US20110200550A1

  公开（公告）日：2011-08-18

  Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.

  本文提供了多臂聚合物共轭物，包括一种醇酸酯连接剂，以及包含这种共轭物的配方和相关的制备和给药方法。还提供了使用这种共轭物进行治疗的方法和相关用途。这些共轭物具有高药物负载效率。
• MULTI-ARM POLYMERIC ALKANOATE CONJUGATES
  申请人：NEKTAR THERAPEUTICS

  公开号：US20150133534A1

  公开（公告）日：2015-05-14

  Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.

  本文提供了包括含有烷酸酯连接物的多臂聚合物共轭物、包含这种共轭物的组合物以及相关的制备和给药方法等方面的内容。还提供了使用这种共轭物的治疗方法和相关用途。这些共轭物具有高药物装载效率。
• Multi-arm polymeric alkanoate conjugates
  申请人：Nektar Therapeutics

  公开号：US10039737B2

  公开（公告）日：2018-08-07

  Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.

  除其他方面外，本文还提供了包含烷酸连接剂的多臂聚合物共轭物、包含此类共轭物的组合物以及制造和施用此类共轭物的相关方法。还提供了使用这种共轭物的治疗方法和相关用途。制备的共轭物具有很高的药物负载效率。
• Chemiluminescence-based haemostasis assay
  申请人：Stichting Katholieke Universiteit

  公开号：US10465230B2

  公开（公告）日：2019-11-05

  The present invention relates to a method for in vitro determining generation of a haemostasis factor such as thrombin and/or plasmin in a test sample using a chemiluminescent substrate specific for said blood clotting factor. Upon cleavage of the substrate, a luminescent signal is generated with the aid of a luciferase. The invention also relates to a kit for in vitro determining generation of a haemostasis factor in a test sample, and to novel chemiluminescent substrates for the determination of thrombin and plasmin.

  本发明涉及一种使用特异性凝血因子化学发光底物体外测定测试样本中凝血因子（如凝血酶和/或凝血酶）生成的方法。底物裂解后，借助荧光素酶产生发光信号。本发明还涉及一种用于体外测定测试样本中止血因子生成量的试剂盒，以及用于测定凝血酶和凝血活酶的新型化学发光底物。
• CHEMILUMINESCENCE-BASED HAEMOSTASIS ASSAY
  申请人：Stichting Katholieke Universiteit

  公开号：EP2652142A1

  公开（公告）日：2013-10-23