N-(2-chloro-4,6-difluorophenyl)-4-(2,4-difluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine | 1242019-36-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(2-chloro-4,6-difluorophenyl)-4-(2,4-difluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine
• 英文别名: N-(2-chloro-4,6-difluorophenyl)-4-(2,4-difluorophenyl)-2,5-dimethylpyrazol-3-amine
• CAS: 1242019-36-8
• 化学式: C₁₇H₁₂ClF₄N₃
• 分子量: 369.749
• InChiKey: INFARVMXVOIJBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  29.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] FUNGICIDAL PYRAZOLES<br/>[FR] PYRAZOLES FONGICIDES
  申请人：DU PONT

  公开号：WO2010101973A1

  公开（公告）日：2010-09-10

  Disclosed are compounds of Formula (1), including all geometric and stereoisomers, JV-oxides, and salts thereof, wherein Q1 is a phenyl ring, naphthalenyl ring system, a 5- to 6-membered fully unsaturated heterocyclic ring or an 8- to 10-membered heteroaromatic bicyclic ring system, each as described with optional substituents as defined in the disclosure; Q2 is a phenyl ring, a naphthalenyl ring system, a 5- to 6-membered saturated, partially unsaturated or fully unsaturated heterocyclic ring, or an 8- to 10-membered heteroaromatic bicyclic ring system, each as described with optional substituents as defined in the disclosure; X is O, S(O)m, NR4, CR15R16, C(O) or C(=S); and R1, R1a, R2, R4, R15, R16 and m are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention. Also disclosed are compounds of Formula (2), including all geometric and stereoisomers, and salts thereof, wherein X is NH; and Q1, Q2 and R2 are as defined for Formula (1); which are useful as intermediates for preparing compounds of Formula (1).

  公开的是Formula (1)的化合物，包括所有的几何和立体异构体，JV-氧化物及其盐，其中Q1是苯环，萘环系统，5-至6-成员完全不饱和的杂环环或8-至10-成员的杂芳双环系统，每个如披露中定义的可选取代基；Q2是苯环，萘环系统，5-至6-成员饱和的、部分不饱和的或完全不饱和的杂环环，或8-至10-成员的杂芳双环系统，每个如披露中定义的可选取代基；X是O，S(O)m，NR4，CR15R16，C(O)或C(=S)；而R1、R1a、R2、R4、R15、R16和m如披露中定义。还公开了含有Formula (1)的化合物的组合物以及用于控制由真菌病原体引起的植物疾病的方法，包括施用本发明的化合物或组合物的有效量。还公开了Formula (2)的化合物，包括所有的几何和立体异构体，及其盐，其中X是NH；Q1、Q2和R2如Formula (1)中定义；它们可作为制备Formula (1)的化合物的中间体。
• FUNGICIDAL PYRAZOLES
  申请人：Long Jeffrey Keith

  公开号：US20110319430A1

  公开（公告）日：2011-12-29

  Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein Q 1 is a phenyl ring, naphthalenyl ring system, a 5- to 6-membered fully unsaturated heterocyclic ring or an 8- to 10-membered heteroaromatic bicyclic ring system, each as described with optional substituents as defined in the disclosure; Q 2 is a phenyl ring, a naphthalenyl ring system, a 5- to 6-membered saturated, partially unsaturated or fully unsaturated heterocyclic ring, or an 8- to 10-membered heteroaromatic bicyclic ring system, each as described with optional substituents as defined in the disclosure; X is O, S(O) m , NR 4 , CR 15 R 16 , C(═O) or C(═S); and R 1 , R 1a , R 2 , R 4 , R 15 , R 16 and m are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention. Also disclosed are compounds of Formula 2, including all geometric and stereoisomers, and salts thereof, wherein X is NH; and Q 1 , Q 2 and R 2 are as defined for Formula 1; which are useful as intermediates for preparing compounds of Formula 1.

  本发明涉及一种化合物，其化学式为1，包括所有几何和立体异构体，N-氧化物和其盐，其中Q1是苯环，萘环系统，5-至6-成员完全不饱和的杂环环或8-至10-成员的杂芳香双环系统，每个如所述，其可选取代基如定义在本说明书中；Q2是苯环，萘环系统，5-至6-成员饱和，部分不饱和或完全不饱和的杂环环或8-至10-成员的杂芳香双环系统，每个如所述，其可选取代基如定义在本说明书中；X是O，S（O）m，NR4，CR15R16，C（═O）或C（═S）；以及R1、R1a、R2、R4、R15、R16和m如本说明书所定义。本发明还涉及包含化合物1的组合物以及用于控制由真菌病原体引起的植物病害的方法，包括施用本发明的化合物或组合物的有效量。本发明还涉及化合物2，其化学式为2，包括所有几何和立体异构体以及其盐，其中X为NH；Q1、Q2和R2如化合物1所定义；其作为制备化合物1的中间体有用。
• FUNGICIDAL PYRAZOLES AND THEIR MIXTURES
  申请人：Long Jeffrey Keith

  公开号：US20130129839A1

  公开（公告）日：2013-05-23

  Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1, N-oxides, and salts thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the disclosure; and (b) at least one additional fungicidal compound. Also disclosed is a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of a compound of Formula 1, an N-oxide, or salt thereof (e.g., as a component in the aforesaid composition). Also disclosed is a composition comprising: (a) at least one compound selected from the compounds of Formula 1 described above, N-oxides, and salts thereof; and at least one invertebrate pest control compound or agent.

  本发明公开了一种杀真菌组合物，包括（a）至少一种选择自式1化合物、N-氧化物和其盐的化合物，其中R1、R2、R3、R4、R5和R6如本公开所定义；（b）至少一种额外的杀真菌化合物。本发明还公开了一种控制由真菌植物病原体引起的植物病害的方法，包括向植物或其部分，或植物种子施加式1化合物、N-氧化物或其盐的杀真菌有效量（例如，作为上述组合物的组分）。本发明还公开了一种组合物，包括：（a）至少一种选择自上述式1化合物、N-氧化物和其盐的化合物；和至少一种无脊椎动物害虫控制化合物或剂。
• Fungicidal pyrazoles
  申请人：E. I. du Pont de Nemours and Company

  公开号：EP2403834A1

  公开（公告）日：2012-01-11
• US9107412B2
  申请人：——

  公开号：US9107412B2

  公开（公告）日：2015-08-18