2-(4-cyclopropane-sulfonyl-phenyl)-2-(2,4-difluoro-phenoxy)-N-(5-pyrazol-1-yl-thiazol-2-yl)acetamide | 1328991-06-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-cyclopropane-sulfonyl-phenyl)-2-(2,4-difluoro-phenoxy)-N-(5-pyrazol-1-yl-thiazol-2-yl)acetamide
• 英文别名: 2-(4-cyclopropylsulfonylphenyl)-2-(2,4-difluorophenoxy)-N-(5-pyrazol-1-yl-1,3-thiazol-2-yl)acetamide
• CAS: 1328991-06-5
• 化学式: C₂₃H₁₈F₂N₄O₄S₂
• 分子量: 516.549
• InChiKey: LACMPBISTMFOKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  140
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATION
  申请人：Bhuniya Debnath

  公开号：US20100310493A1

  公开（公告）日：2010-12-09

  Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these acetamide derivatives.

  乙酰胺衍生物，它们的立体异构体、互变异构体、前药、药用可接受盐、多型体、溶剂合物及其配方，用于预防、管理、治疗、控制疾病和/或医疗状况的进展，或者作为激活葡萄糖激酶有益时的辅助治疗，已被披露。该披露还提供了这些乙酰胺衍生物的制备方法。
• ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATIONS
  申请人：Bhuniya Debnath

  公开号：US20120214735A1

  公开（公告）日：2012-08-23

  Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these acetamide derivatives.

  本文披露了乙酰胺衍生物及其立体异构体、互变异构体、前药、药学上可接受的盐、多晶形、溶剂化物和制剂，用于预防、管理、治疗、控制进展或辅助治疗激活葡萄糖激酶有益的疾病和/或医疗条件。此外，本文还提供了制备这些乙酰胺衍生物的过程。
• US8501955B2
  申请人：——

  公开号：US8501955B2

  公开（公告）日：2013-08-06
• US9340506B2
  申请人：——

  公开号：US9340506B2

  公开（公告）日：2016-05-17