N-[3-[(7-amino-1,8-naphthyridin-2-yl)amino]propyl]-3-[[3-[3-[(7-amino-1,8-naphthyridin-2-yl)amino]propylamino]-3-oxopropyl]amino]propanamide | 1100194-20-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[3-[(7-amino-1,8-naphthyridin-2-yl)amino]propyl]-3-[[3-[3-[(7-amino-1,8-naphthyridin-2-yl)amino]propylamino]-3-oxopropyl]amino]propanamide
• CAS: 1100194-20-4
• 化学式: C₂₈H₃₇N₁₁O₂
• 分子量: 559.674
• InChiKey: MDAXCOXGUCTDIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  41
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  198
• 氢给体数：
  7
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  4-((tert-butoxy)carbonylamino)-N-(3-oxopropyl)butanamide 、 N-[3-[(7-amino-1,8-naphthyridin-2-yl)amino]propyl]-3-[[3-[3-[(7-amino-1,8-naphthyridin-2-yl)amino]propylamino]-3-oxopropyl]amino]propanamide 在 sodium cyanoborohydride 、 溶剂黄146 、 三乙胺 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以86 mg的产率得到
  参考文献：
  名称：

  Dimer of 2,7-diamino-1,8-naphthyridine for the detection of mismatches formed by pyrimidine nucleotide bases

  摘要：

  Discrimination of base mismatches from normal Watson-Crick base pairs in duplex DNA constitutes a key approach to the detection of single nucleotide polymorphisms ( SNPs). We have developed a sensor for a surface plasmon resonance (SPR) assay system to detect G-G, A-A, and C-C mismatch duplexes by employing a surface upon which mismatch-binding ligands (MBLs) are immobilized. We synthesized a new MBL consisting of 2,7-diamino-1,8-naphthyridine (damND) and immobilized it onto a CM5 sensor chip to carry out the SPR assay of DNA duplexes containing a single-base mismatch. The SPR sensor with damND revealed strong responses to all C-C mismatches, and sequence-dependent C-T and T-T mismatches. Compared to ND- and naphthyridine-azaquinolone hybrid (NA)-immobilized sensor surfaces, with affinity to mismatches composed of purine nucleotide bases, the damND-immobilized surface was useful for the detection of the mismatches composed of pyrimidine nucleotide bases. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2008.10.035
• 作为产物：
  描述：

  tert-butyl bis(3-((3-((7-amino-1,8-naphthyridin-2-yl)amino)propyl)amino)-3-oxopropyl)carbamate 在 盐酸 、 水 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 反应 1.0h， 生成 N-[3-[(7-amino-1,8-naphthyridin-2-yl)amino]propyl]-3-[[3-[3-[(7-amino-1,8-naphthyridin-2-yl)amino]propylamino]-3-oxopropyl]amino]propanamide
  参考文献：
  名称：

  Dimer of 2,7-diamino-1,8-naphthyridine for the detection of mismatches formed by pyrimidine nucleotide bases

  摘要：

  Discrimination of base mismatches from normal Watson-Crick base pairs in duplex DNA constitutes a key approach to the detection of single nucleotide polymorphisms ( SNPs). We have developed a sensor for a surface plasmon resonance (SPR) assay system to detect G-G, A-A, and C-C mismatch duplexes by employing a surface upon which mismatch-binding ligands (MBLs) are immobilized. We synthesized a new MBL consisting of 2,7-diamino-1,8-naphthyridine (damND) and immobilized it onto a CM5 sensor chip to carry out the SPR assay of DNA duplexes containing a single-base mismatch. The SPR sensor with damND revealed strong responses to all C-C mismatches, and sequence-dependent C-T and T-T mismatches. Compared to ND- and naphthyridine-azaquinolone hybrid (NA)-immobilized sensor surfaces, with affinity to mismatches composed of purine nucleotide bases, the damND-immobilized surface was useful for the detection of the mismatches composed of pyrimidine nucleotide bases. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2008.10.035

文献信息

• Dimer of 2,7-diamino-1,8-naphthyridine for the detection of mismatches formed by pyrimidine nucleotide bases
  作者：Akio Kobori、Kazuhiko Nakatani

  DOI：10.1016/j.bmc.2008.10.035

  日期：2008.12.15

  Discrimination of base mismatches from normal Watson-Crick base pairs in duplex DNA constitutes a key approach to the detection of single nucleotide polymorphisms ( SNPs). We have developed a sensor for a surface plasmon resonance (SPR) assay system to detect G-G, A-A, and C-C mismatch duplexes by employing a surface upon which mismatch-binding ligands (MBLs) are immobilized. We synthesized a new MBL consisting of 2,7-diamino-1,8-naphthyridine (damND) and immobilized it onto a CM5 sensor chip to carry out the SPR assay of DNA duplexes containing a single-base mismatch. The SPR sensor with damND revealed strong responses to all C-C mismatches, and sequence-dependent C-T and T-T mismatches. Compared to ND- and naphthyridine-azaquinolone hybrid (NA)-immobilized sensor surfaces, with affinity to mismatches composed of purine nucleotide bases, the damND-immobilized surface was useful for the detection of the mismatches composed of pyrimidine nucleotide bases. (C) 2008 Published by Elsevier Ltd.