1-Naphthalen-2-yl-3-p-tolyl-propane-1,3-dione | 57114-81-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-Naphthalen-2-yl-3-p-tolyl-propane-1,3-dione
• 英文别名: 1-(4-Methylphenyl)-3-naphthalen-2-ylpropane-1,3-dione
• CAS: 57114-81-5
• 化学式: C₂₀H₁₆O₂
• 分子量: 288.346
• InChiKey: WTANGYORJMZLNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Naphthalen-2-yl-3-p-tolyl-propane-1,3-dione 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以84%的产率得到2,2-dibromo-1-(naphthalen-2-yl)-3-p-tolylpropane-1,3-dione
  参考文献：
  名称：

  N-溴代琥珀酰亚胺的溶剂控制的1,3-二酮的α-单溴化，α，α-二溴化或酰亚胺化

  摘要：

  一块石头，两只鸟！用N-溴代琥珀酰亚胺开发了一种溶剂控制的区域选择性方法，用于α-单溴化，α，α-二溴化或酰亚胺化1,3-二酮。1,3-二酮的二溴化在乙腈中借助可见光辐射有效地进行。发现一种重要的原甲酸三乙酯溶剂对1,3-二酮的单溴化非常有效，也是在无碱条件下进行酰亚胺化反应的理想介质。

  DOI：

  10.1002/ejoc.201800994

文献信息

• COMPOSITIONS AND METHODS FOR MAKING AND USING OXYGEN SENSING NANOFIBERS AND SCAFFOLDS
  申请人：University of Virginia Patent Foundation

  公开号：US20160041177A1

  公开（公告）日：2016-02-11

  To address the need for scaffold-based oxygen concentration monitoring, a single-component, self-referenced oxygen sensor was made into nanofibers. Electrospinning process parameters were tuned to produce a biomaterial scaffold with specific morphological features. The ratio of an oxygen sensitive phosphorescence signal to an oxygen insensitive fluorescence signal was calculated at each image pixel to determine an oxygenation value. A single component boron dye-polymer conjugate was chosen for additional investigation due to improved resistance to degradation in aqueous media compared to a dye polymer blend. Standardization curves show that in fully supplemented media, the fibers are responsive to dissolved oxygen concentrations less than 15 parts per million. Spatial and temporal ratiometric gradients were observed in vitro radiating outward from the center of a dense adherent cell grouping. Sensor activation in ischemia and cell transplant models in vivo show oxygenation decreases on the scale of minutes.
• US7955861B2
  申请人：——

  公开号：US7955861B2

  公开（公告）日：2011-06-07
• US9874566B2
  申请人：——

  公开号：US9874566B2

  公开（公告）日：2018-01-23