N-benzyl-4-(2,5-dimethylthiophen-3-yl)-3-(2-methyl-1H-indol-3-yl)maleimide | 947407-98-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-benzyl-4-(2,5-dimethylthiophen-3-yl)-3-(2-methyl-1H-indol-3-yl)maleimide
• CAS: 947407-98-9
• 化学式: C₂₆H₂₂N₂O₂S
• 分子量: 426.539
• InChiKey: OQYWTSURRCIVKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.63
• 重原子数：
  31.0
• 可旋转键数：
  4.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  53.17
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  N-benzyl-4-(2,5-dimethylthiophen-3-yl)-3-(2-methyl-1H-indol-3-yl)maleimide 在 氢氧化钾 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 以73%的产率得到3-(2,5-dimethylthiophen-3-yl)-4-(2-methyl-1H-indol-3-yl)maleic anhydride
  参考文献：
  名称：

  A convenient synthesis of 3,4-diaryl(hetaryl)-substituted maleimides and maleic anhydrides

  摘要：

  A convenient procedure has been developed for the synthesis of 3,4-diaryl(or hetaryl)maleimides by cross coupling of N-substituted 3,4-dibromomaleimides with aryl(hetaryl)boronic acids in the presence of Pd(Ph3P)(4) and CsF The reaction ensures high yields of the products and requires relatively small amount of the catalyst; it can be performed on an enlarged scale. The resulting maleimides are readily converted into the corresponding maleic anhydrides.

  DOI：

  10.1134/s1070428006100162
• 作为产物：
  描述：

  N-benzyl-3-[1-(tert-butoxycarbonyl)-2-methyl-1H-indol-3-yl]-4-(2,5-dimethylthiophen-3-yl)maleimide 在 苄胺 作用下， 反应 0.67h， 以100%的产率得到N-benzyl-4-(2,5-dimethylthiophen-3-yl)-3-(2-methyl-1H-indol-3-yl)maleimide
  参考文献：
  名称：

  A convenient synthesis of 3,4-diaryl(hetaryl)-substituted maleimides and maleic anhydrides

  摘要：

  A convenient procedure has been developed for the synthesis of 3,4-diaryl(or hetaryl)maleimides by cross coupling of N-substituted 3,4-dibromomaleimides with aryl(hetaryl)boronic acids in the presence of Pd(Ph3P)(4) and CsF The reaction ensures high yields of the products and requires relatively small amount of the catalyst; it can be performed on an enlarged scale. The resulting maleimides are readily converted into the corresponding maleic anhydrides.

  DOI：

  10.1134/s1070428006100162