2-chlorobenzyl 4-chlorophenyl sulfoxide | 17530-87-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chlorobenzyl 4-chlorophenyl sulfoxide
• 英文别名: 1-Chloro-2-[(4-chlorophenyl)sulfinylmethyl]benzene；1-chloro-2-[(4-chlorophenyl)sulfinylmethyl]benzene
• CAS: 17530-87-9
• 化学式: C₁₃H₁₀Cl₂OS
• 分子量: 285.194
• InChiKey: WPVHBWULRVQLJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (2-chloro-benzyl)-(4-chloro-phenyl)-sulfide 在 双氧水 、 溶剂黄146 作用下， 生成 2-chlorobenzyl 4-chlorophenyl sulfoxide
  参考文献：
  名称：

  An Innovative Approach to Clinical Communication in Schizophrenia: The Approaches to Schizophrenia Communication Checklists

  摘要：

  摘要抗精神病药物的副作用会对患者的生活产生深远的影响，并可能对他们遵从治疗的意愿产生不利影响。通过改善精神科医生、医疗团队其他成员和患者之间的沟通来识别副作用，可能会提高治疗依从性。精神分裂症沟通方法（ASC）指导小组开发了两份简单实用的核对表，可在繁忙的临床环境中使用。ASC-自我报告（ASC-SR）核对表由患者填写，包含一份抗精神病治疗中较为常见或临床上较为重要的副作用清单。ASC-临床（ASC-C）核对表由临床医生和患者共同完成，作为半结构化访谈的基础。在一项为评估核对表效用而设立的多中心试点研究中，86%的受访患者认为 ASC-SR 有助于向精神科医生和医疗团队的其他成员传达他们的问题。所有医疗团队的受访者都认为这两份核对表有助于他们与患者讨论副作用问题。此外，分别有 41% 和 47% 的医疗团队受访者表示，ASC-SR 和 ASC-C 有助于他们发现之前没有意识到的副作用问题。这项多中心试点研究对ASC-SR和ASC-C的初步评估表明，这两种工具对用户都很友好，能鼓励患者和医护人员就抗精神病药物的副作用进行交流，并能很容易地融入日常临床实践中。

  DOI：

  10.1017/s1092852900022045

文献信息

• Nuclear Magnetic Resonance Studies of Sulfur Compounds. II. The Substituent Effect on Geminal Coupling Constants and on Magnetic Nonequivalence of the Methylene Protons of Sulfoxides.
  作者：Motohiro Nishio

  DOI：10.1248/cpb.15.1669

  日期：——

  Nuclear magnetic resonance spectra were obtained for a number of sulfoxides, whose methylene protons are magnetically nonequivalent. The coupling constants between these protons depend on the electronic properties of the substituent adjacent to the coupling protons. The substituent effect on magnetic nonequivalence was also studied and it is demonstrated that the electronic properties of the substituent constitute an important factor responsible for the magnitude of magnetic nonequivalence.

  为若干亚砜得到了核磁共振谱，它们的甲撑质子在磁性上是属于非等性的。这些质子之间的偶合常数依赖于和偶合质子临近的取代基的电子性质。也对取代基对磁性非等性的影响作了研究，并证明取代基的电子性质是对磁性非等性大小起决定作用的一个重要因素。
• Selective Oxidation of Sulfides to Sulfoxides and Sulfones Using<b><i>n</i></b>-Butyltriphenylphosphonium Dichromate (Bu^<i>n</i>PPh₃)₂Cr₂O₇in the Presence of Aluminium Chloride in Solution and Under Microwave Irradiation
  作者：Iraj Mohammadpoor-Baltork、Hamid Reza Memarian、Kiumars Bahrami、Karim Esmayilpour

  DOI：10.1080/104265090968091

  日期：2005.12

  sulfones in excellent yields using n-butyltriphenylphosphonium dichromate (BTPPDC) in the presence of aluminium chloride in acetonitrile solution and under microwave irradiation. In addition, selective oxidation of sulfides in the presence of functional groups such as a carbon–carbon double bond, ketone, oxime, aldehyde, ether, and acetal can be considered as a noteworthy advantage of this method.

  使用正丁基三苯基重铬酸鏻 (BTPPDC) 在乙腈溶液中的氯化铝存在下并在微波辐射下，可以将多种硫化物有效氧化为相应的亚砜和砜，产率极好。此外，在碳-碳双键、酮、肟、醛、醚和缩醛等官能团存在下选择性氧化硫化物可被认为是该方法的显着优势。
• 3-Carboxypyridinium chlorochromate – aluminium chloride — An efficient and inexpensive reagent system for the selective oxidation of sulfides to sulfoxides and sulfones in solution and under microwave irradiation
  作者：Iraj Mohammadpoor-Baltork、Hamid R Memarian、Kiumars Bahrami

  DOI：10.1139/v05-008

  日期：2005.2.1

  3-Carboxypyridinium chlorochromate (CPCC) in the presence of aluminium chloride is a very efficient reagent for the selective oxidation of sulfides to sulfoxide and sulfones in solution and under microwave irradiation. It is noteworthy that different functional groups including carbon–carbon double bonds, ketones, oximes, aldehydes, ethers, and acetals were tolerated under these reaction conditions.Key words: sulfoxides, sulfones, oxidation, chlorochromate, Lewis acid.

  3-羧基吡啶氯铬酸铵（CPCC）在铝氯化物存在下是一种非常有效的试剂，可在溶液中并在微波辐射下选择性氧化硫化物为亚砜和砜。值得注意的是，在这些反应条件下，不同的官能团，包括碳-碳双键、酮、肟、醛、醚和缩醛都能耐受。关键词：亚砜、砜、氧化、氯铬酸铵、Lewis酸。
• An Innovative Approach to Clinical Communication in Schizophrenia: The Approaches to Schizophrenia Communication Checklists
  作者：Sharon G. Dott、Peter Weiden、Penelope Hopwood、A. George Awad、Jonathan S.E. Hellewell、John Knesevich、Lili Kopala、Alexander Miller、Carl Salzman

  DOI：10.1017/s1092852900022045

  日期：2001.11

  Side effects from antipsychotic medications can have a profound effect on patients' lives and may adversely affect their willingness to comply with treatment. Identification of side effects through improved communication between psychiatrists, other members of the healthcare team, and their patients might increase treatment compliance. The Approaches to Schizophrenia Communication (ASC) Steering Group developed two simple, practical checklists for use in the busy clinical setting. The ASC–Self-Report (ASC-SR) checklist is completed by the patient and comprises a list of the more common or clinically important side effects of antipsychotic treatment. The ASC-Clinic (ASC-C) checklist is completed by both clinician and patient together, being used as the basis for a semi-structured interview. In a multicenter pilot study set up to evaluate the utility of checklists, 86% of patients responding considered the ASC-SR to be useful in communicating their problems to psychiatrists and other members of the healthcare team. All healthcare team respondents found both checklists to be helpful when discussing side effect problems with their patients. Moreover, 41% and 47% of healthcare team respondents reported that the ASC-SR and ASC-C, respectively, had assisted them in identifying side-effect problems not previously acknowledged. Preliminary evaluation of the ASC-SR and ASC-C in this multicenter pilot study suggests that both tools were user-friendly, encouraged communication between patients and healthcare professionals about antipsychotic drug side effects, and could readily integrated into everyday clinical practice.

  摘要抗精神病药物的副作用会对患者的生活产生深远的影响，并可能对他们遵从治疗的意愿产生不利影响。通过改善精神科医生、医疗团队其他成员和患者之间的沟通来识别副作用，可能会提高治疗依从性。精神分裂症沟通方法（ASC）指导小组开发了两份简单实用的核对表，可在繁忙的临床环境中使用。ASC-自我报告（ASC-SR）核对表由患者填写，包含一份抗精神病治疗中较为常见或临床上较为重要的副作用清单。ASC-临床（ASC-C）核对表由临床医生和患者共同完成，作为半结构化访谈的基础。在一项为评估核对表效用而设立的多中心试点研究中，86%的受访患者认为 ASC-SR 有助于向精神科医生和医疗团队的其他成员传达他们的问题。所有医疗团队的受访者都认为这两份核对表有助于他们与患者讨论副作用问题。此外，分别有 41% 和 47% 的医疗团队受访者表示，ASC-SR 和 ASC-C 有助于他们发现之前没有意识到的副作用问题。这项多中心试点研究对ASC-SR和ASC-C的初步评估表明，这两种工具对用户都很友好，能鼓励患者和医护人员就抗精神病药物的副作用进行交流，并能很容易地融入日常临床实践中。
• Tin(II) Polyoxometalate as an Efficient Catalyst for the Selective Oxidation of Sulfides to Sulfoxides
  作者：Ezzat Rafiee、Iraj M. Baltork、Shahram Tangestaninejad、Alireza Azad、Sepideh Moinee

  DOI：10.1515/znb-2006-0516

  日期：2006.5.1

  The applicability of the tin(II) polyoxometalate catalyst, [(n-C₄H₉)₄N]₅PSnMo₂W₉O₃₉ · 9H₂O, for sulfoxidation of diaryl, dibenzyl, aryl benzyl, dialkyl, cyclic, and heterocyclic sulfides with 30% hydrogen peroxide was examined under organic halogen-free condition. It is noteworthy that different functional groups including carbon-carbon double bonds, ketones, oximes, aldehydes, ethers, alcohols, and acetals were tolerated under this reaction condition.

  二价锡聚氧化金属酸盐催化剂[(n-C4H9)4N]5PSnMo2W9O39·9H2O，在有机卤素自由条件下，用30%过氧化氢对二芳基、二苄基、芳基苄基、二烷基、环状和杂环硫醚进行了研究。值得注意的是，在这种反应条件下，不同的功能基团，包括碳-碳双键、酮、肟、醛、醚、醇和缩醛都能耐受。