1-(2-chlorophenyl)-N-[(4-chlorophenyl)methyl]methanimine | 55329-09-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-chlorophenyl)-N-[(4-chlorophenyl)methyl]methanimine
• CAS: 55329-09-4
• 化学式: C₁₄H₁₁Cl₂N
• 分子量: 264.154
• InChiKey: ADWFOTNPJYQIEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(2-chlorophenyl)-N-[(4-chlorophenyl)methyl]methanimine 以 丙酮 、 甲苯 为溶剂， 反应 4.5h， 生成 [PtCl{2-MeC₆H₃CH=NCH₂(4-ClC₆H₄)}PPh₃]
  参考文献：
  名称：

  Regioselective C–H Activation Preceded by C_sp²–C_sp³ Reductive Elimination from Cyclometalated Platinum(IV) Complexes

  摘要：

  Reductive elimination reactions of the cyclometalated platinum-(IV) compounds [PtMe2Cl{C6H4CH=NCH2(4-ClC6H4)}L] and [PtMe2Br{C6H4CH=NCH2(C6H5)}L] (L = SMe2, PPh3) to form C-sp3-C-sp2 bonds, followed by either exclusive C H bond activation (L = SMe2) or competition between C-sp2-H and C-sp3-H bond activation (L = PPh3), are reported. Isomerization to give endo products instead of the expected exo complex was observed for the ligand C6H4CH=NCH2(2-BrC6H5), and formation of an endo six-membered platinacycle occurs for the ligand 2,4,6-Me3C6H2CH=NCH2(2-BrC6H4).

  DOI：

  10.1021/om400398g
• 作为产物：
  描述：

  2-氯苯甲醛 、 对氯苄胺 在 溶剂黄146 作用下， 以 乙腈 为溶剂， 反应 2.0h， 以78%的产率得到1-(2-chlorophenyl)-N-[(4-chlorophenyl)methyl]methanimine
  参考文献：
  名称：

  A one-pot synthesis of highly substituted tetrahydropyridines from N-benzylidenemethanamines, dialkyl acetylenedicarboxylates and benzylidenemalononitriles

  摘要：

  A simple and efficient synthesis of highly substituted tetrahydropyridines has been developed using a one-pot, two step reactions. The synthesis of a series of N-benzylidenemethanamines from benzylamines and benzaldehydes in the presence of acetic acid, followed by cyclization with dialkyl acetylenedicarboxylates and benzylidenemalononitriles, gave the corresponding tetrahydropyridines in good yields.

  DOI：

  10.3998/ark.5550190.p009.701

文献信息

• A one-pot synthesis of highly substituted tetrahydropyridines from N-benzylidenemethanamines, dialkyl acetylenedicarboxylates and benzylidenemalononitriles
  作者：Hossein Mehrabi、Ahmad Mohebbi

  DOI：10.3998/ark.5550190.p009.701

  日期：——

  A simple and efficient synthesis of highly substituted tetrahydropyridines has been developed using a one-pot, two step reactions. The synthesis of a series of N-benzylidenemethanamines from benzylamines and benzaldehydes in the presence of acetic acid, followed by cyclization with dialkyl acetylenedicarboxylates and benzylidenemalononitriles, gave the corresponding tetrahydropyridines in good yields.
• Regioselective C–H Activation Preceded by C_sp²–C_sp³ Reductive Elimination from Cyclometalated Platinum(IV) Complexes
  作者：Craig M. Anderson、Margarita Crespo、Nicole Kfoury、Michael A. Weinstein、Joseph M. Tanski

  DOI：10.1021/om400398g

  日期：2013.8.12

  Reductive elimination reactions of the cyclometalated platinum-(IV) compounds [PtMe2ClC6H4CH=NCH2(4-ClC6H4)}L] and [PtMe2BrC6H4CH=NCH2(C6H5)}L] (L = SMe2, PPh3) to form C-sp3-C-sp2 bonds, followed by either exclusive C H bond activation (L = SMe2) or competition between C-sp2-H and C-sp3-H bond activation (L = PPh3), are reported. Isomerization to give endo products instead of the expected exo complex was observed for the ligand C6H4CH=NCH2(2-BrC6H5), and formation of an endo six-membered platinacycle occurs for the ligand 2,4,6-Me3C6H2CH=NCH2(2-BrC6H4).