1-methyl-3-[2-(5-methyloxazol-2-yl)ethyl]-1H-indole | 1062323-71-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-methyl-3-[2-(5-methyloxazol-2-yl)ethyl]-1H-indole
• 英文别名: 5-Methyl-2-[2-(1-methylindol-3-yl)ethyl]-1,3-oxazole；5-methyl-2-[2-(1-methylindol-3-yl)ethyl]-1,3-oxazole
• CAS: 1062323-71-0
• 化学式: C₁₅H₁₆N₂O
• 分子量: 240.305
• InChiKey: AVLDNZOSYXUUEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  31
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-(1-methyl-1H-indol-3-yl)-N-propargylpropionamide 在 gold(III) chloride 作用下， 以 二氯甲烷 为溶剂， 反应 15.0h， 以63%的产率得到1-methyl-3-[2-(5-methyloxazol-2-yl)ethyl]-1H-indole
  参考文献：
  名称：

  Gold- and Silver-Mediated Cycloisomerizations of N-Propargylamides

  摘要：

  Substituted N-propargylamides have proven to be valuable substrates for alkyne-activated cycloisomerization reactions. N-Tosyl-N'-propargylurea underwent reaction with AuCl3 to give the corresponding dihydroimidazolone, while N-propargyl-3-oxobutanamides and esters were used to construct furanyl fused pyrrolldinones and dihydrofuranones via Ag(I)-mediated alkyne activation.

  DOI：

  10.1021/ol801847j

文献信息

• Gold- and Silver-Mediated Cycloisomerizations of <i>N</i>-Propargylamides
  作者：Guido Verniest、Albert Padwa

  DOI：10.1021/ol801847j

  日期：2008.10.2

  Substituted N-propargylamides have proven to be valuable substrates for alkyne-activated cycloisomerization reactions. N-Tosyl-N'-propargylurea underwent reaction with AuCl3 to give the corresponding dihydroimidazolone, while N-propargyl-3-oxobutanamides and esters were used to construct furanyl fused pyrrolldinones and dihydrofuranones via Ag(I)-mediated alkyne activation.