1-Chloro-4-(1-cyclopentylethyl)benzene | 1221406-65-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Chloro-4-(1-cyclopentylethyl)benzene
• CAS: 1221406-65-0
• 化学式: C₁₃H₁₇Cl
• 分子量: 208.731
• InChiKey: YTNNZWTYMKBXDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  对氯苯乙酮 、 环戊烯 在 四氟硼酸-二乙醚络合物 、 [(C₆H₆)(PCy₃)(CO)RuH]⁺*BF₄⁻ 、 氢气 作用下， 以 氯苯 为溶剂， 110.0 ℃ 、202.66 kPa 条件下， 反应 15.0h， 以30%的产率得到1-Chloro-4-(1-cyclopentylethyl)benzene
  参考文献：
  名称：

  Intermolecular Dehydrative Coupling Reaction of Aryl Ketones with Cyclic Alkenes Catalyzed by a Well-Defined Cationic Ruthenium−Hydride Complex: A Novel Ketone Olefination Method via Vinyl C−H Bond Activation

  摘要：

  The cationic ruthenium hydride complex[(eta(6)-C(6)H(6))-(PCy(3))(CO)RuH](+)BF(4)(-) was found to be a highly effective catalyst for the intermolecular olefination reaction of aryl ketones with cycloalkenes. The preliminary mechanistic analysis revealed that an electrophilic ruthenium vinyl complex is the key species fir mediating both vinyl C-H bond activation and the dehydrative olefination steps of the coupling reaction.

  DOI：

  10.1021/om100051h

文献信息

• Ceramide derivatives as modulators of immunity and autoimmunity
  申请人：Porcelli A. Steven

  公开号：US20070238673A1

  公开（公告）日：2007-10-11

  α-Galactosylceramides and glycosylceramides (“ceramide-like glycolipids”) that modulate NK T cells. The ceramide-like glycolipids vary in the cytokines induced in NK T cells and vary in the antigen-presenting cells that are capable of efficiently presenting the compounds to NK T cells. Pharmaceutical compositions of the ceramide-like glycolipids are provided, as are pharmaceutical compositions of the ceramide-like glycolipids combined with dendritic cells. Methods utilizing the ceramide-like glycolipids in vaccines, to activate NK T cells, to stimulate the immune system, and to treat mammals are also provided. The invention also provides methods of evaluating a compound for its ability to activate an NK T cell in the presence of a cell expressing a CD1d protein.
• US8022043B2
  申请人：——

  公开号：US8022043B2

  公开（公告）日：2011-09-20