3-(3,3-Difluorocyclobutyl)-1,2-oxazol-5-amine | 2228389-02-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(3,3-Difluorocyclobutyl)-1,2-oxazol-5-amine
• CAS: 2228389-02-2
• 化学式: C₇H₈F₂N₂O
• 分子量: 174.15
• InChiKey: SLRCLGGSYMZHDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  52
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• RET KINASE INHIBITORS
  申请人：Eli Lilly and Company

  公开号：US20220144816A1

  公开（公告）日：2022-05-12

  Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.
• [EN] PYRAZOLE DERIVATIVES ASR ET KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE PYRAZOLE EN TANT QU'INHIBITEURS DE KINASE RET
  申请人：[en]ELI LILLY AND COMPANY

  公开号：WO2022098970A1

  公开（公告）日：2022-05-12

  Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.