1-Propyl-2,5-dimethyl-imidazol | 24029-27-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-Propyl-2,5-dimethyl-imidazol
• 英文别名: 2,5-dimethyl-1-propyl-1H-imidazole；2,5-Dimethyl-1-propylimidazole
• CAS: 24029-27-4
• 化学式: C₈H₁₄N₂
• 分子量: 138.213
• InChiKey: XIIAQPYHQMKZCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• PROCESS FOR THE MANUFACTURE OF ACETIC ACID
  申请人：HALLINAN NOEL C.

  公开号：US20120264971A1

  公开（公告）日：2012-10-18

  The disclosure relates to a process in which methanol is carbonylated in a reaction zone in the presence of a catalyst to obtain a reaction mixture (A) comprising acetic acid, hydrogen iodide, methyl iodide, water and the catalyst. At least a part of the reaction mixture (A) is separated in a flash zone to obtain a vapor stream (B V ) which comprises acetic acid, hydrogen iodide, methyl iodide and water. The vapor stream (B V ) is withdrawn from the flash zone, and the withdrawn vapor stream is then reacted with at least one alkylimidazole to obtain a composition (C) from which acetic acid is separated. By reacting the vapor stream (B V ) with the alkylimidazole at least parts of the hydrogen iodide and methyl iodide contained in (B V ) are bound in form of iodide salts which significantly facilitates the separation of crude acetic acid from the vapor stream (B V ) and the further purification of the crude acetic acid.
• Process for the Production of Acetic Acid
  申请人：Hallinan Noel C.

  公开号：US20120310009A1

  公开（公告）日：2012-12-06

  The disclosure relates to a process in which methanol is carbonylated in a reaction zone in the presence of a catalyst to obtain a reaction mixture (A) comprising acetic acid, hydrogen iodide, methyl iodide, water and the catalyst. At least a part of the reaction mixture (A) is withdrawn from the reaction zone. The withdrawn part of the reaction mixture (A) is introduced into a flash zone where it is brought into contact with an alkylimidazolium iodide to form a secondary mixture (B), and where the secondary mixture (B) is separated to obtain a vapor stream (B V ) which comprises the acetic acid, water and methyl iodide, and a liquid stream (B L ) which comprises the catalyst, the alkylimidazolium iodide and hydrogen iodide. The vapor stream (B V ) is processed to purify the acetic acid, and the liquid stream (B L ) is recycled to the reaction zone. The reaction mixture (A) is brought into contact with the alkylimidazolium iodide in the flash zone 1) by introducing to the flash zone separately from the withdrawn part of the reaction mixture (A) an extraneous alkylimidazolium iodide; or 2) by introducing to the flash zone separately from the withdrawn part of the reaction mixture (A) an alkylimidazole and forming the alkylimidazolium iodide in situ by reacting the alkylimidazole with the hydrogen iodide or the methyl iodide.
• ITRACONAZOLE ANALOGS AND USE THEREOF
  申请人：The Johns Hopkins University

  公开号：US20220106302A1

  公开（公告）日：2022-04-07

  Itraconazole, a widely used antifungal drug, has been found to possess potent anti-angiogenic and anti-hedgehog activities, exhibiting promising antitumor activity in several human clinical studies. The wider use of itraconazole in the treatment of cancer, however, has been limited by its potent inhibition of the drug metabolic enzyme CYP3A4 which causes drug-drug interactions. In an effort to eliminate the CYP3A4 inhibition of itraconazole while retaining its anti-angiogenic activity, we synthesized a series of itraconazole derivatives. The newly synthesized analogs of itraconazole were evaluated for their cytotoxicity against human umbilical vein endothelial cells (HUVEC) and their inhibitory activity against CYP3A4 enzyme.
• US8637699B2
  申请人：——

  公开号：US8637699B2

  公开（公告）日：2014-01-28
• US8742168B2
  申请人：——

  公开号：US8742168B2

  公开（公告）日：2014-06-03