1,3,5-trimethyl-3-phenylindolin-2-one | 1188327-86-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1,3,5-trimethyl-3-phenylindolin-2-one
• 英文别名: 1,3,5-Trimethyl-3-phenylindol-2-one；1,3,5-trimethyl-3-phenylindol-2-one
• CAS: 1188327-86-7
• 化学式: C₁₇H₁₇NO
• 分子量: 251.328
• InChiKey: FDSQVBBWCDEAJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-methyl-N-(2-chloro-4-methylphenyl)-2-phenylpropanoic acid amide 在 palladium diacetate 、 di-1-adamantylphosphine oxide 、 sodium t-butanolate 作用下， 以 1,4-二氧六环 为溶剂， 反应 18.0h， 以80%的产率得到1,3,5-trimethyl-3-phenylindolin-2-one
  参考文献：
  名称：

  Air-Stable Secondary Phosphine Oxide as Preligand for Palladium-Catalyzed Intramolecular α-Arylations with Chloroarenes

  摘要：

  A palladium catalyst derived from air-stable secondary phosphine oxide (1-Ad)(2)P(O)H enabled efficient intramolecular alpha-arylations of amides with aryl chlorides, which allowed for the synthesis of diversely substituted (aza)oxindoles.

  DOI：

  10.1021/ol901597d

文献信息

• Remote Construction of N‐Heterocycles via 1,4‐Palladium Shift‐Mediated Double C−H Activation
  作者：Takeru Miyakoshi、Nadja E. Niggli、Olivier Baudoin

  DOI：10.1002/anie.202116101

  日期：2022.4.19

  AbstractIn the past years, Pd0‐catalyzed C(sp3)−H activation provided efficient and step‐economical methods to synthesize carbo‐ and heterocycles via direct C(sp2)−C(sp3) bond formation. We report herein that a 1,4‐Pd shift allows access to N‐heterocycles which are difficult to build via a direct reaction. It is shown thato‐bromo‐N‐methylanilines undergo a 1,4‐Pd shift at theN‐methyl group, followed by intramolecular trapping by C(sp2)−H or C(sp3)−H activation at another nitrogen substituent and remote C−C bond formation to generate biologically relevant isoindolines and β‐lactams. The product selectivity is influenced by the employed ligand, with NHCs favoring the product of remote C−C coupling against products arising from direct C−C coupling and N‐demethylation.
• Air-Stable Secondary Phosphine Oxide as Preligand for Palladium-Catalyzed Intramolecular α-Arylations with Chloroarenes
  作者：Lutz Ackermann、Rubén Vicente、Nora Hofmann

  DOI：10.1021/ol901597d

  日期：2009.10.1

  A palladium catalyst derived from air-stable secondary phosphine oxide (1-Ad)(2)P(O)H enabled efficient intramolecular alpha-arylations of amides with aryl chlorides, which allowed for the synthesis of diversely substituted (aza)oxindoles.