3-[(2-{3-[(2-{2-[Bis-(2-methoxycarbonyl-ethyl)-amino]-ethylcarbamoyl}-ethyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-propionylamino}-ethyl)-(2-methoxycarbonyl-ethyl)-amino]-propionic acid methyl ester | 724427-34-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[(2-{3-[(2-{2-[Bis-(2-methoxycarbonyl-ethyl)-amino]-ethylcarbamoyl}-ethyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-propionylamino}-ethyl)-(2-methoxycarbonyl-ethyl)-amino]-propionic acid methyl ester
• CAS: 724427-34-3
• 化学式: C₃₃H₆₀N₆O₁₂
• 分子量: 732.872
• InChiKey: GQUZXEYFXKLEER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.32
• 重原子数：
  51.0
• 可旋转键数：
  27.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  211.45
• 氢给体数：
  3.0
• 氢受体数：
  15.0

反应信息

• 作为反应物：
  描述：

  三氟乙酸 、 3-[(2-{3-[(2-{2-[Bis-(2-methoxycarbonyl-ethyl)-amino]-ethylcarbamoyl}-ethyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-propionylamino}-ethyl)-(2-methoxycarbonyl-ethyl)-amino]-propionic acid methyl ester 反应 7.0h， 生成
  参考文献：
  名称：

  Synthesis and energy-transfer properties of poly(amidoamine) dendrons modified with naphthyl and dansyl groups

  摘要：

  Poly(amidoamine) dendrons of 1-3 generations with naphthyl groups at the periphery and a dansyl group at the focal point were synthesized and carefully characterized. Intramolecular energy-transfer properties of these flexible aliphatic-scaffold light-harvesting dendrons were investigated by UV-vis absorption and fluorescence spectroscopy. Efficient energy transfer from the naphthyl groups to the dansyl group occurred for both the first and the second generation dendrons (the energy-transfer efficiency was 94.3% and 76.9%, respectively), whereas the third generation dendron exhibited a low energy-transfer efficiency of 17.8%. The average donor-acceptor distances between the naphthyl and dansyl groups were calculated for different generation dendrons. Different degrees of the backfolding of dendritic branches were used to interpret the different donor-acceptor distances. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.01.083
• 作为产物：
  描述：

  二碳酸二叔丁酯 以 甲醇 、 二氯甲烷 为溶剂， 反应 72.0h， 生成 3-[(2-{3-[(2-{2-[Bis-(2-methoxycarbonyl-ethyl)-amino]-ethylcarbamoyl}-ethyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-propionylamino}-ethyl)-(2-methoxycarbonyl-ethyl)-amino]-propionic acid methyl ester
  参考文献：
  名称：

  Synthesis and photoluminescence study of di-dendron dendrimers derived from mono-Boc-protected ethylenediamine cores

  摘要：

  这项工作聚焦于以单Boc保护的乙二胺（EDA）作为核心的圆锥形结构特征二树枝聚酰胺树枝状聚合物的合成和光学性质，研究至第三代。研究了不同末端基团（-NH2，-COOCH3）的二树枝聚合物在不同条件下的强紫外吸收光谱和荧光光谱，通过改变实验参数如浓度和pH进行研究。随着二树枝聚合物的代数从0.5增加到3.0，光学密度和荧光强度均有所增加。确认了二树枝聚合物的浓度在荧光强度中起重要作用。荧光强度在低浓度区呈线性增加，但在高浓度区增加缓慢。结果还显示，在低pH下荧光强度快速增加。荧光发射部分的形成与来源于单Boc保护EDA核心的二树枝聚合物中的质子化三级胺基团有密切关系。此外，荧光化学物种的形成是不可逆的。版权 © 2010 John Wiley & Sons, Ltd.

  DOI：

  10.1002/bio.1223

文献信息

• Synthesis and Unimolecular Micelles of Amphiphilic Dendrimer-like Star Polymer with Various Functional Surface Groups
  作者：Weiqiang Cao、Lei Zhu

  DOI：10.1021/ma1021242

  日期：2011.3.22

  amide coupling between the carboxylic acid-terminated PLLA star polymer and six PAMAM dendrons, amphiphilic DLSPs were successfully synthesized. To enhance bioactivity and bioconjugation capability, the benzyl ester surface groups in these DLSPs were converted to carboxylic acid, primary amine, and triethylene glycol functional groups, respectively. Nuclear magnetic resonance spectroscopy and size-exclusion

  我们报告与疏水性的星形聚（1-丙交酯）（PLLA）核心和亲水性聚（酰胺基胺）（PAMAM）树突壳的两亲树状大分子状星形聚合物（DLSPs）的合成和功能化。首先，通过l的开环聚合合成羧酸官能化的PLLA星形聚合物-丙交酯，然后用琥珀酸酐官能化。其次，通过发散法制备了在树突根上具有伯胺，在外围具有苄基酯保护基的1、2、3和3代PAMAM树突。通过羧酸封端的PLLA星形聚合物与6个PAMAM树突之间的酰胺偶联，成功合成了两亲性DLSP。为了增强生物活性和生物共轭能力，将这些DLSP中的苄基酯表面基团分别转化为羧酸，伯胺和三甘醇官能团。核磁共振波谱法和尺寸排阻色谱法用于确认定量功能化。通过动态光散射研究，这些功能性DLSP在水溶液中表现出独特的单分子胶束（14-28 nm）行为，具有少量聚集（205-344 nm）。另外，它们还表现出很大的热行为差异，这取决于不同表面基团的性质。实验结果表明，这些
• The synthesis of unsymmetrical PAMAM dendrimers using a divergent/divergent approach
  作者：Ian K Martin、Lance J Twyman

  DOI：10.1016/s0040-4039(00)02001-3

  日期：2001.2

  The synthesis of unsymmetrical dendrimers possessing terminal methyl ester groups on one face, and iso-butylamide groups on the opposite face is reported. The anal unsymmetrical dendrimers are obtained in high purity and therefore do not require complicated or excessive purification procedures. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Butylamide-terminated poly(amidoamine) dendritic gelators
  作者：Min Gao、Gui-Chao Kuang、Xin-Ru Jia、Wu-Song Li、Yan Li、Yen Wei

  DOI：10.1016/j.tetlet.2008.08.008

  日期：2008.10

  Butylamide-terminated poly(amidoamine) dendrons with either a Boc group (C-n (n = 1, 2, 3)) or a carboxyl group (E-n (n = 1, 2)) at the focal point, as a new kind of dendritic gelators, were synthesized and their gelation properties were studied by TEM, WAXD, SAXS, NMR,and FTIR spectroscopy. It was found that the Structure of focal groups impacted greatly on their gelation ability and the dendrons with higher generations facilitated the gel phase assembly. Hydrogen-bonding and hydrophobic interactions were proved to be the main driving forces responsible for the fibrous assembly with the diameter in the range of 30-100 nm. The molecular packing pattern of the xerogels of C-2, C-3, E-1, and E-2 all showed a lamellar structure, which was revealed by WAXD and SAXS. (C) 2008 Published by Elsevier Ltd.