1-N-i-Propylcarbamoyloxindole | 102565-82-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-N-i-Propylcarbamoyloxindole
• 英文别名: 2-oxo-N-propan-2-yl-3H-indole-1-carboxamide
• CAS: 102565-82-2
• 化学式: C₁₂H₁₄N₂O₂
• 分子量: 218.255
• InChiKey: TWRSDKHQGTYMOV-UHFFFAOYSA-N

物化性质

• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-吲哚酮 、 异氰酸异丙酯 在 环己烷 作用下， 以 甲苯 为溶剂， 反应 22.0h， 以giving 7.0 g of the title compound, mp 84°-85.5° C.的产率得到1-N-i-Propylcarbamoyloxindole
  参考文献：
  名称：

  1,3-dicarboxamidooxindoles as analgesic and antiinflammatory agents

  摘要：

  1,3-二羧酰胺氧吲哚作为抗炎药物，通过1-氨甲酰氧吲哚与异氰酸酯反应或相应的烷基1-氨甲酰氧吲哚-3-羧酸酯的氨解反应制备。

  公开号：

  US04791129A1

文献信息

• 1,3-dicarboxamide-oxindoles as antiinflammatory agents
  申请人：Pfizer Inc.

  公开号：US04725616A1

  公开（公告）日：1988-02-16

  1,3-Dicarboxamidooxindoles as antiinflammatory agents prepared by reaction of the 1-carbamoyloxindole with an isocyanate or by aminolysis of the corresponding alkyl 1-carbamoyloxindole-3-carboxylate.

  1,3-二羧酰胺基吲哚作为抗炎药物，通过1-羰胺氧吲哚与异氰酸酯的反应或通过相应的烷基1-羰胺氧吲哚-3-羧酸酯的氨解反应制备。
• N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and
  申请人：Pfizer Inc.

  公开号：US04569942A1

  公开（公告）日：1986-02-11

  Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also further substituted on the carboxamide nitrogen by an alkyl, cycloalkyl, phenyl or substituted phenyl group, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and antiinflammatory agents in mammalian subjects. These 2-oxindole-1-carboxamide compounds are of particular value for ameliorating pain in human patients recovering from surgery or trauma, and alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and osteoarthritis, in human subjects. Certain 2-oxindole-1-carboxamide compounds unsubstituted at C-3, but having a substituent on the carboxamide nitrogen, are useful as intermediates to the analgesic and antiinflammatory agents of the invention.

  在3位置具有酰基取代基，并且在羧酰胺氮上进一步取代为烷基、环烷基、苯基或取代苯基团的某些2-氧吲哚-1-羧酰胺化合物，是环氧合酶（CO）和脂氧合酶（LO）酶的抑制剂，并且在哺乳动物主体中作为镇痛和抗炎药物是有用的。这些2-氧吲哚-1-羧酰胺化合物对于缓解人类手术或创伤恢复中的疼痛，以及缓解人类主体的慢性疾病症状，如类风湿性关节炎和骨关节炎，具有特殊价值。在C-3未取代的某些2-氧吲哚-1-羧酰胺化合物，但在羧酰胺氮上具有取代基，可作为本发明中的镇痛和抗炎药物的中间体。
• N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
  申请人：PFIZER INC.

  公开号：EP0164860A1

  公开（公告）日：1985-12-18

  Certain 2-oxindole-lcarboxamide compounds having an acyl substituent at the 3-position, and also further substituted on the carboxamide nitrogen by an alkyl, cycloalkyl, phenyl or substituted phenyl group, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and antiinflammatory agents in mammalian subjects. These 2-oxindole-lcarboxamide compounds are of particular value for ameliorating pain in human patients recovering from surgery or trauma, and alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and ostoarthritis, in human subjects. Certain 2-oxind ole-1-carboxamide compounds unsubstituted at C-3, but having a substituent on the carboxamide nitrogen, are useful as intermediates to the analgesic and antiinflammatory agents of the invention.

  某些 2-氧吲哚-甲酰胺化合物在 3 位上具有酰基取代基，在羧酰胺氮上还进一步被烷基、环烷基、苯基或取代苯基取代，是环氧化酶（CO）和脂氧合酶（LO）的抑制剂，可用作哺乳动物的镇痛剂和抗炎剂。这些 2-氧化吲哚-甲酰胺化合物对于改善手术或创伤后恢复期人类患者的疼痛，以及减轻人类慢性疾病（如类风湿性关节炎和骨关节炎）的症状具有特殊价值。 某些在 C-3 处未被取代但在羧酰胺氮上具有取代基的 2-氧代吲哚-1-甲酰胺化合物可作为本发明镇痛剂和抗炎剂的中间体。
• Substituted 2-oxindole-1-carboxamide intermediates
  申请人：PFIZER INC.

  公开号：EP0244918A2

  公开（公告）日：1987-11-11

  2-Oxindole-1-carboxamide intermediates of the formula: wherein X and Y are each hydrogen, 5-fluoro, 6-fluoro, 5-chloro, 6-chloro, 5-trifluoromethyl or 6-trifluoromethyl, provided that X and Y are not both hydrogen; and R is alkyl having from 1 to 6 carbons, cycloalkyl having from 3 to 7 carbons, benzyl, furyl, thienyl, pyridyl or a group of the formula wherein R1 and R2 are each hydrogen, fluoro, chloro, alkyl having 1 to 4 carbons, alkoxy having 1 to 4 carbons or trifluoromethyl.

  2-吲哚-1-甲酰胺中间体，其式如下： 其中 X 和 Y 分别为氢、5-氟、6-氟、5-氯、6-氯、5-三氟甲基或 6-三氟甲基，条件是 X 和 Y 不同时为氢；R 为具有 1 至 6 个碳原子的烷基、具有 3 至 7 个碳原子的环烷基、苄基、呋喃基、噻吩基、吡啶基或式中 R1 和 R2 分别为氢、氟、氯、具有 1 至 4 个碳原子的烷基、具有 1 至 4 个碳原子的烷氧基或三氟甲基的基团。
• 1-Substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents
  申请人：PFIZER INC.

  公开号：EP0208510B1

  公开（公告）日：1991-09-11