tert-butyl (2S)-2-benzyl-4-methyl-6-methylidene-3-oxopiperazine-1-carboxylate | 1140404-80-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl (2S)-2-benzyl-4-methyl-6-methylidene-3-oxopiperazine-1-carboxylate
• CAS: 1140404-80-3
• 化学式: C₁₈H₂₄N₂O₃
• 分子量: 316.4
• InChiKey: IFCMRBTYNOJKIQ-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (S)-2-(t-butoxycarbonylamino)-N-methyl-3-phenyl-N-(1,2-propadienyl)propanamide 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以8%的产率得到
  参考文献：
  名称：

  Entry to nitrogen-containing heterocycles by based-promoted heterocyclization on allenylamides of l-α-aminoacids

  摘要：

  Allenylamides of Boc-protected alpha-aminoacids easily gave in basic medium heterocyclic products arising from attack of the NH group on the inside C-C double bond of the 1,2-diene moiety, namely imidazolidinones, pyrazinones, and a pyrrole compound. The microwave-assisted heterocyclization occurred cleanly at C-beta of the allenyl group with formation of pyrazin-2-ones having an endo- or exocyclic double bond. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.01.074

文献信息

• Entry to nitrogen-containing heterocycles by based-promoted heterocyclization on allenylamides of l-α-aminoacids
  作者：Gianluigi Broggini、Simona Galli、Micol Rigamonti、Silvia Sottocornola、Gaetano Zecchi

  DOI：10.1016/j.tetlet.2009.01.074

  日期：2009.4

  Allenylamides of Boc-protected alpha-aminoacids easily gave in basic medium heterocyclic products arising from attack of the NH group on the inside C-C double bond of the 1,2-diene moiety, namely imidazolidinones, pyrazinones, and a pyrrole compound. The microwave-assisted heterocyclization occurred cleanly at C-beta of the allenyl group with formation of pyrazin-2-ones having an endo- or exocyclic double bond. (C) 2009 Elsevier Ltd. All rights reserved.