methyl-2-aminopyrimidine[3,2-b]olean-12-ene-28-methyl ester | 122305-08-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: methyl-2-aminopyrimidine[3,2-b]olean-12-ene-28-methyl ester
• CAS: 122305-08-2
• 化学式: C₃₃H₄₉N₃O₂
• 分子量: 519.771
• InChiKey: CJENUFCNZDHUFB-FPFQSWSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.88
• 重原子数：
  38.0
• 可旋转键数：
  1.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  78.83
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  methyl-2-aminopyrimidine[3,2-b]olean-12-ene-28-methyl ester 在 辛胺 、 lithium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以78%的产率得到(1R,2R,11R,14R,15S,18S,23S)-7-amino-2,10,10,14,15,21,21-heptamethyl-6,8-diazahexacyclo[12.12.0.02,11.04,9.015,24.018,23]hexacosa-4,6,8,24-tetraene-18-carboxylic acid
  参考文献：
  名称：

  Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B

  摘要：

  A series of maslinic acid derivatives have been synthesized by introducing various fused heterocyclic rings at C-2 and C-3 positions. Their inhibitory effects on PTP1B, TCPTP and related PTPs are evaluated. Most of the compounds exhibited a dramatic increase in inhibitory potency and selectivity, the two most potent PTP1B inhibitors 20 (IC50 = 0.61 mu M) and 29 (IC50 = 0.64 mu M) showed about 10-fold more potent than lead compound maslinic acid. More importantly, 29 possesses the best selectivity of 6.9-fold for PTP1B over TCPTP. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.017
• 作为产物：
  描述：

  盐酸胍 、 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以70%的产率得到methyl-2-aminopyrimidine[3,2-b]olean-12-ene-28-methyl ester
  参考文献：
  名称：

  Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B

  摘要：

  A series of maslinic acid derivatives have been synthesized by introducing various fused heterocyclic rings at C-2 and C-3 positions. Their inhibitory effects on PTP1B, TCPTP and related PTPs are evaluated. Most of the compounds exhibited a dramatic increase in inhibitory potency and selectivity, the two most potent PTP1B inhibitors 20 (IC50 = 0.61 mu M) and 29 (IC50 = 0.64 mu M) showed about 10-fold more potent than lead compound maslinic acid. More importantly, 29 possesses the best selectivity of 6.9-fold for PTP1B over TCPTP. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.017

文献信息

• Reddy, R. Prasad; Ravindranath, A.; Sudhakar, B., Journal of the Indian Chemical Society, 1988, vol. 65, # 10, p. 688 - 690
  作者：Reddy, R. Prasad、Ravindranath, A.、Sudhakar, B.、Ramaiah, T. Sundara、Rao, M. Venkateshwer

  DOI：——

  日期：——