diethyl (2Z)-2-(1H-pyrrol-2-yl)fumarate | 177742-78-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: diethyl (2Z)-2-(1H-pyrrol-2-yl)fumarate
• 英文别名: diethyl (E)-2-(1H-pyrrol-2-yl)but-2-enedioate
• CAS: 177742-78-8
• 化学式: C₁₂H₁₅NO₄
• 分子量: 237.255
• InChiKey: SLZRZOYUTBEAPX-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  68.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  吡咯 、 丁炔二酸二乙酯 在 potassium tetrachloroplatinate 、 silver trifluoromethanesulfonate 作用下， 以 溶剂黄146 为溶剂， 反应 2.0h， 以43%的产率得到diethyl (2Z)-2-(1H-pyrrol-2-yl)fumarate
  参考文献：
  名称：

  Pt(II)-catalyzed hydroarylation reaction of alkynes with pyrroles and furans

  摘要：

  A Pt(II) catalyst showed a drastic effect on hydroarylation of alkynes with pyrroles and furans compared with Pd(OAc)(2) catalyst. The hydroarylation reactions proceeded smoothly under mild conditions to double-hydroarylation products in good yields. Mono-adducts Were formed only when the second hydroarylation was inhibited by steric hindrance Of Substrates or low reactivity of the mono-adducts. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.03.022

文献信息

• Pt(II)-catalyzed hydroarylation reaction of alkynes with pyrroles and furans
  作者：Juzo Oyamada、Tsugio Kitamura

  DOI：10.1016/j.tet.2009.03.022

  日期：2009.5

  A Pt(II) catalyst showed a drastic effect on hydroarylation of alkynes with pyrroles and furans compared with Pd(OAc)(2) catalyst. The hydroarylation reactions proceeded smoothly under mild conditions to double-hydroarylation products in good yields. Mono-adducts Were formed only when the second hydroarylation was inhibited by steric hindrance Of Substrates or low reactivity of the mono-adducts. (C) 2009 Elsevier Ltd. All rights reserved.