2-[(2-methoxyphenyl)amino]cyclopentanol | 1179660-00-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-[(2-methoxyphenyl)amino]cyclopentanol
• 英文别名: 2-(2-Methoxyanilino)cyclopentan-1-ol
• CAS: 1179660-00-4
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.272
• InChiKey: ITFIJCOSOKPITF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,2-环氧环戊烷 、 邻甲氧基苯胺 在 aluminum (III) chloride 作用下， 反应 12.0h， 生成 2-[(2-methoxyphenyl)amino]cyclopentanol
  参考文献：
  名称：

  Aminolysis of Epoxides in Ionic Liquid 1-Ethylpyridinium Trifluoroacetate as Green and Efficient Reaction Medium

  摘要：

  Aminolysis of epoxides has been carried out using the ionic liquid 1-ethylpyridinium trifluoroacetate ([EtPy][TFA]) as reaction medium. The reactions went smoothly under mild conditions without any catalyst to afford corresponding -aminoalcohols in high conversions. Moreover, further enhancement in the conversions was observed when AlCl3 was used as Lewis acid catalyst.

  DOI：

  10.1080/00397910802323056

文献信息

• [EN] SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1<br/>[FR] AGONISTES À PETITES MOLÉCULES DU RÉCEPTEUR 1 DE LA NEUROTENSINE
  申请人：SANFORD BURNHAM MED RES INST

  公开号：WO2015200534A3

  公开（公告）日：2016-04-21
• Small Molecule Agonists of Neurotensin Receptor 1
  申请人：Sanford-Burnham Medical Research Institute

  公开号：US20170240514A1

  公开（公告）日：2017-08-24

  Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
• SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1
  申请人：Sanford Burnham Prebys Medical Discovery Institute

  公开号：US20190023665A1

  公开（公告）日：2019-01-24

  Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.